Improved MRI detection of inflammation-induced changes in bone marrow microstructure in mice: a machine learning-enhanced T2 distribution analysis
This study investigated inflammation-induced changes in bone marrow with T2 MRI and MIML. MIML outperformed quantitative scalar T2 analysis, increasingly detecting inflammation and iron sequestration in the hematopoietic bone marrow. T2 MRI with MIML analysis could aid in the early diagnosis and management of inflammatory diseases.
Authors
- Ashish Tiwari (ORCID: https://orcid.org/0000-0001-8520-1829)
- Luise Brock (ORCID: https://orcid.org/0000-0002-4591-4354)
- Galit Saar
- Andreas Maier (ORCID: https://orcid.org/0000-0003-1309-5435)
- Katrien Vandoorne (ORCID: https://orcid.org/0000-0002-8132-8280)
- David Abi Saab
- Lukas Folle (ORCID: https://orcid.org/0000-0002-5395-097X)
- Hadas Ben-Atya (ORCID: https://orcid.org/0000-0002-9221-2494)
- Moti Freiman (ORCID: https://orcid.org/0000-0003-1083-1548)
- Narmeen Haj
Institutions
- Technion – Israel Institute of Technology (IL)
- Friedrich-Alexander-Universität Erlangen-Nürnberg (DE)
Publication Details
- Journal
- European Radiology Experimental
- Published
- 2025-03-26
- DOI
- https://doi.org/10.1186/s41747-025-00574-1
- Citations
- 1
- Primary Topic
- Bone and Joint Diseases
- Type
- article
- Field-Weighted Citation Impact
- 1.72
Funders
- United States - Israel Binational Science Foundation
- Israel Science Foundation
- China-Africa Joint Center for Research and Education, CAS