Sensitive diagnosis of paucibacillary tuberculosis with targeted next-generation sequencing: a molecular diagnostic study
tNGS is a potentially promising test that enables rapid and sensitive diagnosis of TB in children and individuals with extrapulmonary TB. However, the variability in its accuracy for predicting drug resistance in these populations needs to be validated and addressed before its clinical application.
Authors
- Miaoran Wang (ORCID: https://orcid.org/0000-0002-7561-7086)
- Zhong Ren
- Jiao Sun
- Shuihua Lu
- Zhen Huang (ORCID: https://orcid.org/0000-0002-3990-7350)
- Ying Zhang (ORCID: https://orcid.org/0000-0001-5317-3640)
- Yu Chen (ORCID: https://orcid.org/0000-0002-1519-4894)
- Chang Liu (ORCID: https://orcid.org/0009-0005-0222-3376)
- Lichao Fan (ORCID: https://orcid.org/0000-0002-3981-6731)
- Xuhui Liu (ORCID: https://orcid.org/0000-0002-6460-6787)
- Y. H. Yu (ORCID: https://orcid.org/0000-0003-1301-2716)
Institutions
- Shanghai Public Health Clinical Center (CN)
- First Hospital of China Medical University (CN)
- Shenyang 242 Hospital (CN)
- Shenzhen Third People’s Hospital (CN)
- First Affiliated Hospital Zhejiang University (CN)
- China Medical University (CN)
Publication Details
- Journal
- BMC Medicine
- Published
- 2025-03-26
- DOI
- https://doi.org/10.1186/s12916-025-03996-1
- Citations
- 6
- Primary Topic
- Tuberculosis Research and Epidemiology
- Type
- article
- Field-Weighted Citation Impact
- 8.38