Exosomes derived from a mesenchymal-like endometrial regenerative cells ameliorate renal ischemia reperfusion injury through delivery of CD73
These data collected insight into how ERC-Exo facilitated the hydrolysis of proinflammatory ATP to immunosuppressive ADO via CD73. CD73 is a critical modulator of the MAPK signaling pathway, inducing a polarization shift of macrophages towards an anti-inflammatory phenotype. This study highlights the significance of ERC-Exosomal CD73 in contributing to the therapeutic effects against renal I/R.
Authors
- Hong-da Wang
- Zhao-bo Wang
- Hongyu Jiang (ORCID: https://orcid.org/0000-0001-5774-6258)
- Chenglu Sun (ORCID: https://orcid.org/0000-0001-9927-9344)
- Qiang Chen (ORCID: https://orcid.org/0000-0002-1488-1369)
- Shaohua Ren (ORCID: https://orcid.org/0000-0002-4400-9045)
- Yicheng Li
- Yi Ren (ORCID: https://orcid.org/0000-0003-3317-7593)
- Bo Shao (ORCID: https://orcid.org/0000-0002-0063-5116)
- Yi-Yi Xiao
- Hao Wang (ORCID: https://orcid.org/0000-0001-9990-2714)
- Yini Xu
- Xu Liu
- Tong Liu
- Peng-yu Zhao
- Guang-mei Yang
Institutions
- Tianjin University (CN)
- Tianjin Medical University General Hospital (CN)
- Inner Mongolia Medical University (CN)
Publication Details
- Journal
- Stem Cell Research & Therapy
- Published
- 2025-03-26
- DOI
- https://doi.org/10.1186/s13287-025-04275-9
- Citations
- 5
- Primary Topic
- Reproductive System and Pregnancy
- Type
- article
- Field-Weighted Citation Impact
- 3.99
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Tianjin City