Glioblastoma Masquerading as Metastasis in a Routine Follow-Up of a 79-Year-Old Woman

Glioblastoma is the most aggressive and common primary brain tumor. Diagnosis is based on imaging and is confirmed through a brain biopsy. Multimodal treatment, including gross total resection, radiotherapy, and chemotherapy, is typically required. We report a case of a 79-year-old woman, a former smoker, who presented with a headache and generalized weakness and was found to have multiple brain lesions. The patient was diagnosed with glioblastoma and underwent partial resection. Multiple glioblastomas are a rare presentation and can be multicentric or multifocal. Patients with this presentation typically exhibit symptoms of high intracranial pressure. Glioblastomas have a poor prognosis despite multidisciplinary management. Glioblastoma should be considered a differential diagnosis for patients with multiple brain lesions.