Regulatory and disruptive variants in the CLCN2 gene are associated with modified skin color pattern phenotypes in the corn snake
Our genomic, transcriptomic, and functional analyses identify a plasma membrane anion channel to be involved in color pattern development in snakes and show that an active LTR-retrotransposon might be a key driver of trait diversification in corn snakes.
Authors
- Asier Ullate‐Agote (ORCID: https://orcid.org/0000-0002-8595-7703)
- Sergi Roig‐Puiggros (ORCID: https://orcid.org/0000-0001-5909-218X)
- Athanasia C. Tzika (ORCID: https://orcid.org/0000-0002-0831-5221)
- Michel C. Milinkovitch (ORCID: https://orcid.org/0000-0002-2553-0724)
- Sophie A. Montandon
- Denis Jabaudon (ORCID: https://orcid.org/0000-0003-2438-4769)
- Maya Kummrow (ORCID: https://orcid.org/0000-0002-5343-1336)
- Pierre Beaudier (ORCID: https://orcid.org/0000-0003-3812-7966)
- Pierre‐Yves Helleboid
- Leif Andersson
Institutions
- University of Geneva (CH)
- Uppsala University (SE)
- University of Zurich (CH)
- University Hospital of Geneva (CH)
- Navarre Institute of Health Research (ES)
- Bracco (Switzerland) (CH)
- Texas A&M University (US)
Publication Details
- Journal
- Genome biology
- Published
- 2025-03-26
- DOI
- https://doi.org/10.1186/s13059-025-03539-0
- Citations
- 2
- Primary Topic
- Retinal Development and Disorders
- Type
- article
- Field-Weighted Citation Impact
- 1.61
Funders
- Human Frontier Science Program
- Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung
- Université de Genève
- Fondation Ernst et Lucie Schmidheiny