Identification of disease-stage therapeutic responses of mesenchymal stromal cells retrieved from murine osteoarthritic joints
The beneficial effects of BM-MSCs in OA post-local delivery could be attributed to a specific subset of cells able to resist the micro-inflammatory milieu and contribute to cartilage healing and suppression of associated synovial inflammation. Furthermore, data suggest a paradigm of environmentally guided plasticity associated with MSCs upon local delivery in both early and late OA.
Authors
- Swarna Raman
- Aideen E. Ryan (ORCID: https://orcid.org/0000-0002-5831-6783)
- Mary Murphy (ORCID: https://orcid.org/0000-0003-0971-7684)
- Marc C. Levesque (ORCID: https://orcid.org/0000-0001-7398-5136)
- Steven McLoughlin
- Frank Barry (ORCID: https://orcid.org/0000-0002-5535-002X)
- Karen English (ORCID: https://orcid.org/0000-0002-7932-4256)
- Raj Kamath
- Ian J. Hawthorne (ORCID: https://orcid.org/0000-0002-5444-2643)
- Georgina Shaw
- Claire Dooley (ORCID: https://orcid.org/0000-0003-2415-9895)
- Derek W. Morris (ORCID: https://orcid.org/0000-0002-3413-570X)
- E. Mukeria
- Conor Hennessy (ORCID: https://orcid.org/0000-0001-9010-3043)
- P. Mancuso
- Ana Ivanovska (ORCID: https://orcid.org/0000-0001-5911-6882)
- Thomas Ritter (ORCID: https://orcid.org/0000-0001-7709-8489)
- Jamie Reilly (ORCID: https://orcid.org/0000-0002-7474-127X)
- Deborah Van Riet
- Brian H. Johnstone (ORCID: https://orcid.org/0000-0003-2112-3192)
- Amy Burke (ORCID: https://orcid.org/0009-0006-9274-9589)
- Aisling O’Brien (ORCID: https://orcid.org/0000-0001-5520-9694)
Institutions
- National University of Ireland, Maynooth (IE)
- Oregon Health & Science University (US)
- Ollscoil na Gaillimhe – University of Galway (IE)
- AbbVie (United States) (US)
Publication Details
- Journal
- Frontiers in Cell and Developmental Biology
- Published
- 2025-03-26
- DOI
- https://doi.org/10.3389/fcell.2025.1521437
- Citations
- 1
- Primary Topic
- Osteoarthritis Treatment and Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 1.67