Herpes simplex virus type 1 impairs mucosal-associated invariant T cells
Mucosal-associated invariant T cells (MAIT cells) are "unconventional" immune cells that are becoming increasingly appreciated to play important roles in a variety of viral infections. Herpes simplex virus (HSV) causes significant human disease and is a master manipulator of multiple immune functions, but how this virus may control MAIT cells is poorly understood. We discovered that HSV can infect human MAIT cells and impair their functional capacity and also show that MAIT cells exposed to HSV, but which do not show evidence of infection, are similarly impaired. This study therefore identifies an additional immunomodulatory function of HSV.
Authors
- Renee Traves (ORCID: https://orcid.org/0000-0003-4291-8699)
- Alexandra Jane Corbett (ORCID: https://orcid.org/0000-0003-1618-4337)
- Shivam K. Purohit (ORCID: https://orcid.org/0009-0004-8088-1350)
- Barry Slobedman (ORCID: https://orcid.org/0000-0002-9431-6094)
- Jeffrey Y. W. Mak (ORCID: https://orcid.org/0000-0002-8011-4539)
- Allison Abendroth (ORCID: https://orcid.org/0000-0002-9794-4803)
- David C. Tscharke (ORCID: https://orcid.org/0000-0001-6825-9172)
- David P. Fairlie (ORCID: https://orcid.org/0000-0002-7856-8566)
- Carolyn Samer (ORCID: https://orcid.org/0000-0001-7838-9958)
- Lauren Stern (ORCID: https://orcid.org/0000-0002-9455-0008)
- Katherine Willis
- Zoe Emanuel
Institutions
- Australian National University (AU)
- The University of Sydney (AU)
- The University of Queensland (AU)
- The University of Melbourne (AU)
- Peter Doherty Institute (AU)
- ARC Centre of Excellence for Innovations in Peptide and Protein Science (AU)
Publication Details
- Journal
- mBio
- Published
- 2025-03-26
- DOI
- https://doi.org/10.1128/mbio.03887-24
- Citations
- 2
- Primary Topic
- Immune Cell Function and Interaction
- Type
- article
- Field-Weighted Citation Impact
- 1.59
Funders
- University of Sydney
- Department of Health and Aged Care, Australian Government
- National Institutes of Health
- Medical Research Council
- National Health and Medical Research Council