Modeling Krebs cycle from liver, heart and hepatoma mitochondria, supported Complex I as target for specific inhibition of cancer cell proliferation
Our results showed that kinetic modeling and metabolic control analysis allow the identification of high flux-controlling targets in cancer cells that help to design strategies to specifically inhibit their proliferation. This can minimize the toxic effects in normal cells, such as the cardiac ones that are highly sensitive to conventional chemotherapy.
Authors
- Emma Saavedra (ORCID: https://orcid.org/0000-0001-8661-9813)
- Álvaro Marín‐Hernández (ORCID: https://orcid.org/0000-0002-7968-7225)
- Luz Hernández‐Esquivel
- Ricardo Jasso‐Chávez
- Silvia Cecilia Pacheco-Velázquez (ORCID: https://orcid.org/0000-0002-6772-6389)
- R. Daniela Feregrino-Mondragón
- Isis Del Mazo‐Monsalvo
- Rosina Sánchez‐Thomas (ORCID: https://orcid.org/0000-0002-3825-591X)
- Diana Xochiquetzal Robledo‐Cadena (ORCID: https://orcid.org/0000-0002-7287-938X)
Institutions
- Instituto Nacional de Cardiología (MX)
- Universidad Nacional Autónoma de México (MX)
Publication Details
- Journal
- Frontiers in Oncology
- Published
- 2025-03-26
- DOI
- https://doi.org/10.3389/fonc.2025.1557638
- Citations
- 1
- Primary Topic
- Cancer, Hypoxia, and Metabolism
- Type
- article
- Field-Weighted Citation Impact
- 0.94
Funders
- Consejo Nacional de Ciencia y Tecnología