P2Y<sub>14</sub> receptor activation of platelets induces Ca<sup>2+</sup> mobilization and Rho‐GTPase‐dependent motility that requires an interaction with P2Y<sub>1</sub> receptors
Platelets can be activated via P2Y<sub>14</sub> receptor stimulation to induce chemotaxis but not aggregation. Furthermore, this was dependent on concomitant activation of P2Y<sub>1</sub> receptor. Activation of P2Y<sub>14</sub> receptors on platelets may therefore be relevant during inflammation, but cooperation with P2Y<sub>1</sub> receptor activation is required.
Authors
- Khondaker Miraz Rahman (ORCID: https://orcid.org/0000-0001-8566-8648)
- Simon C. Pitchford (ORCID: https://orcid.org/0000-0003-3961-0407)
- Kalwant S. Authi
- Kate Arkless
- Clive Page (ORCID: https://orcid.org/0000-0002-9358-3799)
- Md Monir Hossain (ORCID: https://orcid.org/0000-0003-0064-3658)
- Dingxin Pan
Institutions
- King's College London (GB)
- Mawlana Bhashani Science and Technology University (BD)
Publication Details
- Journal
- British Journal of Pharmacology
- Published
- 2025-03-24
- DOI
- https://doi.org/10.1111/bph.70024
- Citations
- 5
- Primary Topic
- Platelet Disorders and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 8.85
Funders
- British Heart Foundation
- Commonwealth Scholarship Commission
- Medical Research Council