Mucosal‐associated invariant T cells correlate with myocardial ischaemia and remodelling in coronary artery disease
During CAD progression, we observed a decrease in circulating MAIT cells. Enhanced activation and cytotoxicity of MAIT cells are associated with myocardial ischaemia and remodelling in CAD patients with heart failure, potentially triggered by gut microbial leakage. Our findings suggest a novel strategy for monitoring and intervention in disease progression.
Authors
- Xiaolan Ouyang
- Yuman Wu
- Jiafu Wang (ORCID: https://orcid.org/0000-0002-3654-4400)
- Hongxing Wu (ORCID: https://orcid.org/0000-0002-0304-0740)
- Suhua Li (ORCID: https://orcid.org/0000-0002-8254-3855)
- Zhitong Li (ORCID: https://orcid.org/0000-0002-0567-9724)
- Zhuoshan Huang (ORCID: https://orcid.org/0000-0002-6831-5434)
- Yue Li (ORCID: https://orcid.org/0000-0003-0527-6519)
- Xixiang Tang (ORCID: https://orcid.org/0000-0002-8781-7982)
- Yan Lü (ORCID: https://orcid.org/0000-0002-5893-6114)
- Xin Zhou (ORCID: https://orcid.org/0000-0002-6566-9018)
- Song Li (ORCID: https://orcid.org/0000-0001-7679-1548)
- Yi Yang (ORCID: https://orcid.org/0000-0002-5200-0614)
- Qian Chen (ORCID: https://orcid.org/0000-0003-0962-8147)
- Long Peng (ORCID: https://orcid.org/0000-0002-2716-4537)
- Ziyi Peng
Institutions
- Sun Yat-sen University (CN)
- Chinese University of Hong Kong (HK)
- Second Affiliated Hospital of Guangzhou Medical University (CN)
- Third Affiliated Hospital of Sun Yat-sen University (CN)
- Guangzhou Medical University (CN)
Publication Details
- Journal
- Clinical & Translational Immunology
- Published
- 2025-01-01
- DOI
- https://doi.org/10.1002/cti2.70029
- Citations
- 1
- Primary Topic
- IL-33, ST2, and ILC Pathways
- Type
- article
- Field-Weighted Citation Impact
- 0.80
Funders
- National Natural Science Foundation of China
- Sun Yat-sen University
- Basic and Applied Basic Research Foundation of Guangdong Province