Effect of Antihypertensive Drugs on Rapid Decline in Estimated Glomerular Filtration Rate in Japanese Patients With Chronic Kidney Disease
The risk of rapid eGFR decline increased with increasing BP and decreased with controlling BP. Antihypertensive treatment was associated with a higher risk of rapid eGFR decline at all BP levels. For CKD patients with proteinuria, maintaining BP in the high-normal or elevated range may further mitigate this risk.
Authors
- Tsuyoshi Watanabe (ORCID: https://orcid.org/0000-0002-3528-4782)
- Kenta Fujimoto (ORCID: https://orcid.org/0000-0002-4258-3692)
- Kazuhiko Tsuruya (ORCID: https://orcid.org/0000-0002-8390-2928)
- Koichi Asahi (ORCID: https://orcid.org/0000-0002-4318-874X)
- Tsuneo Konta (ORCID: https://orcid.org/0000-0001-7681-6469)
- Ichiei Narita (ORCID: https://orcid.org/0000-0001-7692-3096)
- Masao Kikuchi (ORCID: https://orcid.org/0000-0002-4031-9847)
- Masato Kasahara (ORCID: https://orcid.org/0000-0002-1833-9075)
- Masahide Kondo (ORCID: https://orcid.org/0000-0001-6021-4375)
- Michikazu Nakai (ORCID: https://orcid.org/0000-0003-2240-1510)
- Toshiki Moriyama (ORCID: https://orcid.org/0000-0002-9525-4999)
- Koichi Kaikita (ORCID: https://orcid.org/0000-0003-2962-8056)
- Kunihiro Yamagata (ORCID: https://orcid.org/0000-0002-7407-0410)
- Yugo Shibagaki (ORCID: https://orcid.org/0000-0002-8197-205X)
- Kunitoshi Iseki (ORCID: https://orcid.org/0000-0001-6624-0216)
- Shouichi Fujimoto (ORCID: https://orcid.org/0000-0003-2854-8169)
Institutions
- University of Miyazaki (JP)
- Fukushima Prefectural Culture Center (JP)
- University of Miyazaki Hospital (JP)
Publication Details
- Journal
- American Journal of Hypertension
- Published
- 2025-03-23
- DOI
- https://doi.org/10.1093/ajh/hpaf041
- Primary Topic
- Chronic Kidney Disease and Diabetes
- Type
- article
- Field-Weighted Citation Impact
- 0.00