Progesterone and suicidality in male combat veterans

Our study is the first demonstration of progesterone non-suppression by dexamethasone in suicide attempters. The results of our study underline the significant role of neurobiological mechanisms in the pathophysiology of suicidal behavior in combat veterans. Studies of the relation between neurosteroid function and suicidal behavior may lead to the development of biomarkers for suicidality and facilitate identification of individuals at high suicide risk.