Piceatannol promotes the osteogenic differentiation of human periodontal ligament cells through MAPKs activation
We investigated the effects of piceatannol on the osteogenic differentiation of human periodontal ligament fibroblasts (HPLFs). Treatment with piceatannol increased alkaline phosphatase activity and osteogenic differentiation gene molecules (Osteocalcin and Runx2), but this was attenuated by mitogen-activated protein kinase (MAPK) inhibitors (PD098059 or SB203580). Our data suggest that piceatannol promotes osteogenic differentiation of HPLFs by activating MAPKs.
Authors
- Nobuyuki Takahashi (ORCID: https://orcid.org/0000-0002-9705-662X)
- S. Kawakami (ORCID: https://orcid.org/0000-0002-0733-7621)
- Kouichiro Date
- Hiromu Morimoto
- Hiroko Maruki‐Uchida (ORCID: https://orcid.org/0000-0001-9879-1231)
- Hirofumi Inoue (ORCID: https://orcid.org/0000-0001-7725-3856)
- Mariko Uehara (ORCID: https://orcid.org/0000-0003-0402-0968)
- Sadao Mori (ORCID: https://orcid.org/0000-0003-4723-726X)
Institutions
- Tokyo University of Agriculture (JP)
- Morinaga Institute of Biological Science (JP)
Publication Details
- Journal
- Bioscience Biotechnology and Biochemistry
- Published
- 2025-03-24
- DOI
- https://doi.org/10.1093/bbb/zbaf040
- Primary Topic
- Calpain Protease Function and Regulation
- Type
- article
- Field-Weighted Citation Impact
- 0.00