Associations of Periodontitis With Biological Aging Among U.S. Adults: An Exploratory Mediation Analysis via Lactate
These findings indicate that LDH, an enzyme that converts pyruvate to lactate, mediates the association between periodontitis and biological aging. However, additional longitudinal or interventional studies are needed to more effectively assess causality and confirm our findings.
Authors
- Huan Zhou (ORCID: https://orcid.org/0000-0002-2790-6633)
- Ruoyan Cao (ORCID: https://orcid.org/0000-0003-4152-7450)
- Jiayu Zhang (ORCID: https://orcid.org/0000-0002-9120-6340)
- Yong Li (ORCID: https://orcid.org/0000-0003-4257-032X)
- Li An (ORCID: https://orcid.org/0000-0002-7933-5174)
- Lisa Yang
- Di Miao
Institutions
- Hunan University (CN)
- Guangdong Province Stomatological Hospital (CN)
- Stomatology Hospital (CN)
- Southern Medical University (CN)
- Xi'an Jiaotong University (CN)
- China Medical University (CN)
Publication Details
- Journal
- The Journals of Gerontology Series A
- Published
- 2025-03-23
- DOI
- https://doi.org/10.1093/gerona/glaf061
- Citations
- 1
- Primary Topic
- Oral microbiology and periodontitis research
- Type
- article
- Field-Weighted Citation Impact
- 1.47