Targeting PDGFRA-SHP2 signaling enhances radiotherapy in IDH1-mutant glioma
Combining SHP2 inhibition with RT is a promising therapeutic avenue for IDH-mut glioma by suppressing the activated SHP2-ERK axis.
Authors
- Deanna Tiek (ORCID: https://orcid.org/0000-0002-2881-7691)
- Craig Horbinski (ORCID: https://orcid.org/0000-0001-8340-9992)
- Xiao Song (ORCID: https://orcid.org/0000-0002-3171-4300)
- Bo Hu (ORCID: https://orcid.org/0000-0002-9882-4053)
- Shi‐Yuan Cheng (ORCID: https://orcid.org/0000-0003-1737-0588)
- Runxin Wu (ORCID: https://orcid.org/0009-0001-4417-2694)
- Maya Walker
- Xiaozhou Yu (ORCID: https://orcid.org/0000-0002-9187-2896)
Institutions
- Northwestern University (US)
- Neurological Surgery (US)
- Robert H. Lurie Comprehensive Cancer Center of Northwestern University
Publication Details
- Journal
- Neuro-Oncology
- Published
- 2025-03-25
- DOI
- https://doi.org/10.1093/neuonc/noaf086
- Citations
- 3
- Primary Topic
- Protein Tyrosine Phosphatases
- Type
- article
- Field-Weighted Citation Impact
- 2.42