Activation of JNK/p38 MAPK Signaling Pathway by lncRNA DGCR5 Promotes Nucleus Pulposus Cell Degeneration and Pyroptosis in Intervertebral Disk Degeneration
These data suggest that lncRNA DGCR5 regulates NPC degeneration and pyroptosis to promote IDD through the JNK/p38 MAPK signaling pathway.
Authors
- Lebin Guo
- Chenjun Tian
- Bo‐Wen Zheng (ORCID: https://orcid.org/0000-0002-9308-3794)
- Ming‐Xiang Zou (ORCID: https://orcid.org/0000-0002-4516-3917)
- Pengyu Wang (ORCID: https://orcid.org/0000-0003-3994-7704)
- Shiquan Zhang (ORCID: https://orcid.org/0009-0009-7112-2463)
- Wei Guo (ORCID: https://orcid.org/0000-0003-1946-8765)
- Fusheng Liu
- Hua Zhong (ORCID: https://orcid.org/0000-0002-9358-1582)
- Zhun Xu (ORCID: https://orcid.org/0000-0002-3706-8493)
Institutions
- Central South University (CN)
- Hunan University of Traditional Chinese Medicine (CN)
- Peking University (CN)
- Peking University People's Hospital (CN)
- Second Xiangya Hospital of Central South University (CN)
- University of South China (CN)
Publication Details
- Journal
- Neurosurgery
- Published
- 2025-03-25
- DOI
- https://doi.org/10.1227/neu.0000000000003406
- Citations
- 5
- Primary Topic
- Spine and Intervertebral Disc Pathology
- Type
- article
- Field-Weighted Citation Impact
- 7.36
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Hunan Province