Transitioning From Methadone to Buprenorphine in a Patient With Prolonged QTc Interval in the Setting of Acute Liver Failure

This case report highlights the challenge of estimating methadone half-life in a patient with severe acute liver dysfunction who needs to switch from methadone to buprenorphine. A buprenorphine low-dose induction strategy may reduce the risk and severity of precipitated withdrawal.