PRMT1-mediated modification of H4R3me2a promotes liver cancer progression by enhancing the transcriptional activity of SOX18
This study revealed the clinical relevance of histone H4R3me2a modification in HCC and demonstrated that PRMT1 promotes malignant behavior in HCC cells by modulating H4R3me2a modification in the SOX18 promoter region. The findings elucidate the role and molecular mechanism of PRMT1-mediated histone H4R3me2a modification in HCC progression and highlight the potential clinical applications of PRMT1 inhibitors. These results may provide new insights into the treatment of HCC.
Authors
- Hongyi Zhu (ORCID: https://orcid.org/0000-0001-9643-0790)
- Siying Wang (ORCID: https://orcid.org/0000-0003-0810-8828)
- Haojie Jin (ORCID: https://orcid.org/0000-0001-9295-1951)
- Chenhe Yi (ORCID: https://orcid.org/0000-0003-0809-7196)
- Qiangxin Wu
- Wenxin Qin (ORCID: https://orcid.org/0000-0002-1989-3027)
- Jinhong Chen (ORCID: https://orcid.org/0000-0003-0952-9990)
- Xingling Zheng
- Yuanyuan Lv (ORCID: https://orcid.org/0000-0002-4397-8768)
- Yangyang Zhou (ORCID: https://orcid.org/0000-0002-2964-2803)
- Jiaojiao Zheng (ORCID: https://orcid.org/0009-0009-0299-6909)
- Shenghan Lou (ORCID: https://orcid.org/0000-0001-8826-3160)
- Wei Wu (ORCID: https://orcid.org/0000-0003-3303-6694)
- Qi Li (ORCID: https://orcid.org/0000-0001-9161-497X)
- Haoyu Li (ORCID: https://orcid.org/0009-0004-9836-7747)
- Xiaoxiao Sun (ORCID: https://orcid.org/0000-0003-2328-8644)
- Ling Jing (ORCID: https://orcid.org/0000-0002-4919-8121)
- Ruobing Yu (ORCID: https://orcid.org/0000-0003-0151-0398)
Institutions
- Shanghai Jiao Tong University (CN)
- Fudan University (CN)
- Renji Hospital (CN)
- Shanghai Cancer Institute (CN)
- Shanghai First People's Hospital (CN)
- Huashan Hospital (CN)
Publication Details
- Journal
- Hepatology Communications
- Published
- 2025-03-24
- DOI
- https://doi.org/10.1097/hc9.0000000000000647
- Citations
- 3
- Primary Topic
- Cancer-related gene regulation
- Type
- article
- Field-Weighted Citation Impact
- 2.42