Synthesis and preclinical evaluation of gastrin releasing peptide receptor antagonist [18F]MeTz-PEG2-RM26 for positron emission tomography
These findings demonstrate the effectiveness of the IEDDA click reaction for fluorine-18 labelling of GRPR-targeting PET tracers. Future studies should focus on increasing the hydrophilicity of the imaging probe to improve the targeting properties and biodistribution profile of the radioligand.
Authors
- Lorenzo Jacopo Ilic Balestri (ORCID: https://orcid.org/0000-0002-4664-3445)
- Anna Orlova (ORCID: https://orcid.org/0000-0001-6120-2683)
- Ulrika Rosenström (ORCID: https://orcid.org/0000-0002-0817-8140)
- Jonas Eriksson (ORCID: https://orcid.org/0000-0003-0241-092X)
- Fanny Lundmark (ORCID: https://orcid.org/0000-0002-9153-2832)
- Ayman Abouzayed
- Panagiotis Kanellopoulos (ORCID: https://orcid.org/0000-0002-0617-3936)
- Luke R. Odell (ORCID: https://orcid.org/0000-0001-7658-5103)
- Vladimir Tolmachev (ORCID: https://orcid.org/0000-0002-6122-1734)
- Karim Obeid
- Esther Olaniran Håkansson
Institutions
- Uppsala University (SE)
- Uppsala University Hospital (SE)
- Science for Life Laboratory (SE)
Publication Details
- Journal
- EJNMMI Radiopharmacy and Chemistry
- Published
- 2025-03-26
- DOI
- https://doi.org/10.1186/s41181-025-00336-9
- Citations
- 2
- Primary Topic
- Radiopharmaceutical Chemistry and Applications
- Type
- article
- Field-Weighted Citation Impact
- 2.72
Funders
- Uppsala Universitet