Methylated Arginine Metabolites as Biomarkers for Clinical Status and Response to Type 5 Phosphodiesterase Inhibition in Patients With Fontan Circulation

Plasma concentrations of metabolites that inhibit NO flux are associated with negative clinical outcomes and worse exercise capacity. Moreover, metabolite shifts over time associated with increased NO flux are associated with improved exercise capacity. In patients with a Fontan circulation, the NO pathway modulators ADMA and symmetric dimethyl arginine may be useful as biomarkers of clinical status and predictive of response to PDE5is.

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Publication Details

Journal
Journal of the American Heart Association
Published
2025-03-26
DOI
https://doi.org/10.1161/jaha.124.038061
Citations
1
Primary Topic
Congenital Heart Disease Studies
Type
article
Field-Weighted Citation Impact
1.35
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article

Methylated Arginine Metabolites as Biomarkers for Clinical Status and Response to Type 5 Phosphodiesterase Inhibition in Patients With Fontan Circulation

Victor Zak, Jong Mi Ko, David J. Goldberg, Shelby Kutty et al.
1 citations
Journal of the American Heart Association
Congenital Heart Disease Studies
1.35
article

Methylated Arginine Metabolites as Biomarkers for Clinical Status and Response to Type 5 Phosphodiesterase Inhibition in Patients With Fontan Circulation

Victor Zak, Jong Mi Ko, David J. Goldberg, Shelby Kutty, Fred Wu, Jon Detterich, Michelle Ploutz, Rachel Sullivan, Brian W. McCrindle, Matthew Lewis, Pratik Khare, Todd Nowlen, Anne Le, Ruchira Garg, Kristian C. Becker, Matthew D. Files, Ari Cedars, Daniel J. Penny, Bhargava Chinni, Kurt R. Schumacher, Kevin D. Hill, Allen D. Everett, Jennifer Conway, R. Mark Payne, Roni Jacobsen, Jonathan B. Wagner, Robert Whitehill, Cedric Manlhiot, Rahul H. Rathod, Mark W. W. Russell, Andrew M. Atz, Alexander R. Opotowsky, Mark Cartoski, Gi Beom Kim, Scott E. Fletcher
article en
1 citations

Abstract

Plasma concentrations of metabolites that inhibit NO flux are associated with negative clinical outcomes and worse exercise capacity. Moreover, metabolite shifts over time associated with increased NO flux are associated with improved exercise capacity. In patients with a Fontan circulation, the NO pathway modulators ADMA and symmetric dimethyl arginine may be useful as biomarkers of clinical status and predictive of response to PDE5is.

Journal of the American Heart AssociationVol. 14(7)
Cedars-Sinai Medical Center (US), Cincinnati Children's Hospital Medical Center (US), Boston Children's Hospital (US), Seattle Children's Hospital (US), Monroe Carell Jr. Children's Hospital (US), Children's Mercy Hospital (US), Children's Hospital of Philadelphia (US), Children's Hospital of Los Angeles (US), Johns Hopkins University (US), Medical University of South Carolina (US), University of Toronto (CA), Vanderbilt University (US), University of Utah (US), University of Michigan (US), Great Ormond Street Hospital (GB), Hospital for Sick Children (CA), Carolinas Medical Center (US), Riley Hospital for Children (US), Seoul National University Hospital (KR), Children's Hospital Colorado (US), Nemours Children's Health System (US), Phoenix Children's Hospital (US), Duke Medical Center (US), SickKids Foundation (CA), Children's Healthcare of Atlanta (US), Texas Children's Hospital (US), Boston Children's Museum (US), Stollery Children's Hospital (CA), University College London (GB), Milligan College (US), Columbia University (US), University of Cincinnati Medical Center (US), University of Colorado Denver (US)
Good health and well-being
Openalex Percentile: Top 22%
Congenital Heart Disease Studies
1.35
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