Methylated Arginine Metabolites as Biomarkers for Clinical Status and Response to Type 5 Phosphodiesterase Inhibition in Patients With Fontan Circulation
Plasma concentrations of metabolites that inhibit NO flux are associated with negative clinical outcomes and worse exercise capacity. Moreover, metabolite shifts over time associated with increased NO flux are associated with improved exercise capacity. In patients with a Fontan circulation, the NO pathway modulators ADMA and symmetric dimethyl arginine may be useful as biomarkers of clinical status and predictive of response to PDE5is.
Authors
- Victor Zak (ORCID: https://orcid.org/0000-0002-2954-3194)
- Jong Mi Ko (ORCID: https://orcid.org/0000-0001-5681-1038)
- David J. Goldberg (ORCID: https://orcid.org/0000-0002-8950-439X)
- Shelby Kutty (ORCID: https://orcid.org/0000-0001-9428-0979)
- Fred Wu (ORCID: https://orcid.org/0000-0002-4580-8199)
- Jon Detterich (ORCID: https://orcid.org/0000-0002-2086-9569)
- Michelle Ploutz (ORCID: https://orcid.org/0000-0003-0848-3900)
- Rachel Sullivan (ORCID: https://orcid.org/0000-0001-6996-2038)
- Brian W. McCrindle (ORCID: https://orcid.org/0000-0001-6485-6551)
- Matthew Lewis (ORCID: https://orcid.org/0000-0002-8991-0638)
- Pratik Khare (ORCID: https://orcid.org/0000-0002-1633-8765)
- Todd Nowlen (ORCID: https://orcid.org/0000-0001-9615-6138)
- Anne Le (ORCID: https://orcid.org/0000-0002-2958-8149)
- Ruchira Garg (ORCID: https://orcid.org/0000-0002-7258-6480)
- Kristian C. Becker (ORCID: https://orcid.org/0000-0001-9550-9560)
- Matthew D. Files (ORCID: https://orcid.org/0000-0002-9506-5477)
- Ari Cedars (ORCID: https://orcid.org/0000-0002-9975-5301)
- Daniel J. Penny (ORCID: https://orcid.org/0000-0002-8426-0381)
- Bhargava Chinni (ORCID: https://orcid.org/0000-0002-8889-1084)
- Kurt R. Schumacher (ORCID: https://orcid.org/0000-0001-8659-736X)
- Kevin D. Hill (ORCID: https://orcid.org/0000-0003-4451-3580)
- Allen D. Everett (ORCID: https://orcid.org/0000-0002-5559-6708)
- Jennifer Conway (ORCID: https://orcid.org/0000-0003-4051-2185)
- R. Mark Payne (ORCID: https://orcid.org/0000-0002-6232-3628)
- Roni Jacobsen (ORCID: https://orcid.org/0000-0002-3851-9786)
- Jonathan B. Wagner (ORCID: https://orcid.org/0000-0001-7690-6798)
- Robert Whitehill (ORCID: https://orcid.org/0000-0002-3810-7132)
- Cedric Manlhiot (ORCID: https://orcid.org/0000-0001-9419-7681)
- Rahul H. Rathod (ORCID: https://orcid.org/0000-0002-7149-5421)
- Mark W. W. Russell (ORCID: https://orcid.org/0000-0003-4855-9260)
- Andrew M. Atz (ORCID: https://orcid.org/0000-0002-4744-3832)
- Alexander R. Opotowsky (ORCID: https://orcid.org/0000-0002-6107-2281)
- Mark Cartoski (ORCID: https://orcid.org/0000-0003-2762-086X)
- Gi Beom Kim (ORCID: https://orcid.org/0000-0002-7880-280X)
- Scott E. Fletcher
Institutions
- Cedars-Sinai Medical Center (US)
- Cincinnati Children's Hospital Medical Center (US)
- Boston Children's Hospital (US)
- Seattle Children's Hospital (US)
- Monroe Carell Jr. Children's Hospital (US)
- Children's Mercy Hospital (US)
- Children's Hospital of Philadelphia (US)
- Children's Hospital of Los Angeles (US)
- Johns Hopkins University (US)
- Medical University of South Carolina (US)
- University of Toronto (CA)
- Vanderbilt University (US)
- University of Utah (US)
- University of Michigan (US)
- Great Ormond Street Hospital (GB)
- Hospital for Sick Children (CA)
- Carolinas Medical Center (US)
- Riley Hospital for Children (US)
- Seoul National University Hospital (KR)
- Children's Hospital Colorado (US)
- Nemours Children's Health System (US)
- Phoenix Children's Hospital (US)
- Duke Medical Center (US)
- SickKids Foundation (CA)
- Children's Healthcare of Atlanta (US)
- Texas Children's Hospital (US)
- Boston Children's Museum (US)
- Stollery Children's Hospital (CA)
- University College London (GB)
- Milligan College (US)
- Columbia University (US)
- University of Cincinnati Medical Center (US)
- University of Colorado Denver (US)
Publication Details
- Journal
- Journal of the American Heart Association
- Published
- 2025-03-26
- DOI
- https://doi.org/10.1161/jaha.124.038061
- Citations
- 1
- Primary Topic
- Congenital Heart Disease Studies
- Type
- article
- Field-Weighted Citation Impact
- 1.35