Advantages of updated WHO mutation catalog combined with existing whole-genome sequencing-based approaches for Mycobacterium tuberculosis resistance prediction
The second edition of the WHO MTB mutation catalog does not, by itself, perform better than existing tools for predicting MTB drug resistance. An integrative approach combining the WHO catalog with other genotypic DST methods significantly enhances prediction accuracy.
Authors
- Qi Jiang (ORCID: https://orcid.org/0000-0002-3872-6312)
- Peierdun Mijiti
- Xuecong Zhang (ORCID: https://orcid.org/0000-0001-6584-4923)
- Jialei Liang
- Howard Eugene Takiff (ORCID: https://orcid.org/0000-0002-0480-0860)
- Xu Peng (ORCID: https://orcid.org/0000-0001-9068-102X)
- Qian Gao (ORCID: https://orcid.org/0000-0001-8189-6061)
- Yiwang Chen (ORCID: https://orcid.org/0009-0009-3042-2144)
Institutions
- Shanghai Medical College of Fudan University (CN)
- Xinjiang Medical University (CN)
- Instituto Venezolano de Investigaciones Científicas (VE)
- Wuhan University (CN)
- Renmin Hospital of Wuhan University (CN)
- Shenzhen Third People’s Hospital (CN)
Publication Details
- Journal
- Genome Medicine
- Published
- 2025-03-26
- DOI
- https://doi.org/10.1186/s13073-025-01458-0
- Citations
- 8
- Primary Topic
- Tuberculosis Research and Epidemiology
- Type
- article
- Field-Weighted Citation Impact
- 11.17
Funders
- National Natural Science Foundation of China