Targeted inhibitors of S100A9 alleviate chronic pancreatitis by inhibiting M2 macrophage polarization via the TAOK3-JNK signaling pathway
S100A9 is a significant promoter of M2-like macrophage-induced fibrosis in CP via the TAOK3-JNK signaling pathway. Cobamamide and daptomycin, targeted inhibitors of the S100A9-TAOK3 interaction, may become candidate drugs for CP immunotherapy.
Authors
- Deshi Dong (ORCID: https://orcid.org/0000-0003-3266-4314)
- Xufeng Tao
- Yu Zhan (ORCID: https://orcid.org/0000-0002-7551-5039)
- Hong Xiang (ORCID: https://orcid.org/0000-0001-7827-3592)
- Fangyue Guo (ORCID: https://orcid.org/0009-0007-5272-3859)
- Yu Wu (ORCID: https://orcid.org/0000-0001-9650-9896)
- Dong Shang (ORCID: https://orcid.org/0000-0003-1030-916X)
- Xiaohan Zhai (ORCID: https://orcid.org/0009-0008-3048-9499)
- Linlin Lv
Institutions
- Dalian Medical University (CN)
- First Affiliated Hospital of Dalian Medical University (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-03-25
- DOI
- https://doi.org/10.3389/fimmu.2025.1526813
- Citations
- 3
- Primary Topic
- Pancreatitis Pathology and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 6.02