Neuroprotective effects of arctigenin on cerebral ischemia-reperfusion injury in rats via the EPO/EPOR-JAK2-STAT5 signaling pathway
In conclusion, arctigenin demonstrated neuroprotective properties against CIRI potentially through the EPO/EPOR-JAK2-STAT5 signaling pathway. These findings provide a scientific rationale for further exploration of arctigenin as a therapeutic agent for stroke.
Authors
- Wei Lü (ORCID: https://orcid.org/0000-0003-3041-9200)
- Wenjie Wang (ORCID: https://orcid.org/0000-0002-1842-3576)
- Lingling Zhang (ORCID: https://orcid.org/0000-0001-7423-3761)
- Xu Chen (ORCID: https://orcid.org/0000-0003-0564-2021)
- Yuting Chen (ORCID: https://orcid.org/0000-0001-5273-7299)
- Ting Wang (ORCID: https://orcid.org/0000-0002-4047-0432)
- Shanshan Xu (ORCID: https://orcid.org/0000-0001-6354-3860)
Institutions
- Liaoning University of Traditional Chinese Medicine (CN)
- Taizhou Central Hospital (CN)
- Taizhou University (CN)
Publication Details
- Journal
- Frontiers in Pharmacology
- Published
- 2025-03-26
- DOI
- https://doi.org/10.3389/fphar.2025.1503971
- Primary Topic
- Neuroinflammation and Neurodegeneration Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Science and Technology Plan Project of Taizhou
- Zhejiang Province Public Welfare Technology Application Research Project