THE EFFICACY OF STATINS IN REDUCING CARDIOVASCULAR EVENTS IN PATIENTS WITH CORONARY ARTERY DISEASE: A COMPREHENSIVE SYSTEMATIC REVIEW

Background: Statins significantly reduce cardiovascular events in individuals with coronary artery disease (CAD) by lowering LDL-C levels and modulating inflammatory pathways. Long-term adherence to statin therapy is crucial for sustained cardiovascular protection, preventing disease progression, and reducing the risk of adverse outcomes.Methods: This systematic review adhered to PRISMA 2020 principles and focused exclusively on full-text papers published in English between 2015 and 2025. Editorials and review articles without a DOI were eliminated to preserve the integrity of high-quality sources. A literature review was conducted with esteemed databases like ScienceDirect, PubMed, and SagePub to discover relevant studies.Result: The initial database search yielded over 1000 relevant publications on the topic. Following a comprehensive three-stage screening process, eight studies met the specified inclusion criteria and were selected for in-depth analysis. Each study was subjected to a thorough critical evaluation, enabling a comprehensive analysis of the efficacy of statins in reducing cardiovascular events in patients with coronary artery disease. This systematic method ensured that the analysis relied on high-quality evidence, aligned with the study's objectives, and was capable of providing significant insights into this complex association.Conclusion: Statins show significant effects in reducing cardiovascular events in CAD patients, providing anti-inflammatory benefits, endothelial protection, and vascular function improvement. However, adherence remains a barrier, necessitating future research to enhance patient compliance and explore individualized statin therapy and lipid-lowering strategies for improved long-term outcomes.