Anoctamin 9 determines Ca2+ signals during activation of T-lymphocytes

Upon activation of T-cells and formation of the immunological synapse, ANO9 recruits the Ca²⁺-ATPase (PMCA) to the plasma membrane, which is supported by the scaffolding protein discs large 1 (DLG1). PMCAs maintain low Ca²⁺ levels near ORAI1 channels thereby suppressing Ca²⁺-inhibition of ORAI1 and thus retaining store-operated Ca²⁺ entry (SOCE). It is suggested that ANO9 has a role in interorganelle communication and regulation of cellular protein trafficking, which probably requires its phospholipid scramblase function.