Importance of timely diagnosis of primary adrenal insufficiency in polyglandular autoimmune syndrome type 2

ABSTRACT Polyglandular autoimmune syndrome type 2 (PAS-2) is characterized by the presence of two or more endocrinopathies, including adrenal insufficiency, autoimmune thyroid disease, and type 1 diabetes mellitus. This report highlights a case of a 47-year-old male who presented with chest pain and electrolyte imbalances. Initial assessments revealed primary adrenal insufficiency with positive anti-adrenal antibodies. PAS-2 was diagnosed, and a comprehensive treatment plan was established, underscoring the importance of early recognition in preventing severe complications.