MAIT Cells Promote Cholesterol Excretion Pathways Mitigating Atherosclerosis
Our findings demonstrate a new mechanism for plasma VLDL-C clearance by MAIT cell-mediated cholesterol excretion. The results provide further evidence that immunity is involved in cholesterol homeostasis. Targeting intestinal immunity to regulate cholesterol homeostasis holds promise as a new cholesterol-lowering modality to prevent atherosclerotic cardiovascular disease.
Authors
- Maryse Guérin (ORCID: https://orcid.org/0000-0003-0150-1360)
- Pukar KC (ORCID: https://orcid.org/0000-0002-8690-1795)
- Philippe Lesnik (ORCID: https://orcid.org/0000-0002-6909-7715)
- Farid Ichou (ORCID: https://orcid.org/0000-0001-6293-5133)
- Marie Lhomme (ORCID: https://orcid.org/0000-0002-6335-4506)
- Joel T. Haas (ORCID: https://orcid.org/0000-0002-0028-5988)
- Clément Materne (ORCID: https://orcid.org/0000-0003-2605-2231)
- Agnès Lehuen (ORCID: https://orcid.org/0000-0002-0450-3321)
- Sophie Galier (ORCID: https://orcid.org/0000-0002-8094-3409)
- Joe‐Elie Salem (ORCID: https://orcid.org/0000-0002-0331-3307)
- Kaidi Zhang (ORCID: https://orcid.org/0000-0002-3018-1522)
- C RS Neves
- Hua Wang (ORCID: https://orcid.org/0000-0002-7319-6249)
Institutions
- Inserm (FR)
- Université Paris Cité (FR)
- Institut Pasteur de Lille (FR)
- Centre Hospitalier Universitaire de Lille (FR)
- Sorbonne Université (FR)
- Sorbonne Paris Cité (FR)
- Assistance Publique – Hôpitaux de Paris (FR)
- Pitié-Salpêtrière Hospital (FR)
- National Institute of Health (AM)
- Institut Cochin (FR)
- Fondation pour l’innovation en Cadiométabolisme et Nutrition (FR)
Publication Details
- Journal
- Circulation Research
- Published
- 2025-03-26
- DOI
- https://doi.org/10.1161/circresaha.124.325841
- Citations
- 3
- Primary Topic
- Immune Cell Function and Interaction
- Type
- article
- Field-Weighted Citation Impact
- 2.39
Funders
- Agence Nationale de la Recherche
- Institut National de la Santé et de la Recherche Médicale
- Fondation de France
- China Scholarship Council
- Société Française de Cardiologie
- Sorbonne Université