B/N-doped carbon nano-onions as nanocarriers for targeted breast cancer therapy

Cancer is one of the leading causes of death worldwide and represents a significant burden on global health systems. Many existing chemotherapy treatments come with severe side effects, ranging from hair loss to cardiotoxicity, and many types of cancer express chemotherapy resistance, such as triple-negative breast cancer. This study presents a novel boron/nitrogen-doped carbon nano-onion (BN-CNO) based nanocarrier system that can deliver doxorubicin (DOX) to cancer cells <i>via</i> a pH-dependent drug release mechanism. The nanocarrier formulation consists of a hyaluronic acid/phospholipid conjugate (HA-DMPE) that is non-covalently bound to the BN-CNOs upon which DOX is loaded <i>via</i> π-π stacking interactions. The HA-DMPE/BN-CNO/DOX system enhances the uptake and anticancer effects of DOX in MDA-MB-468 and MDA-MB-231 TNBC cells whilst reducing the cardiotoxicity of DOX in AC-16 human cardiomyocytes.

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Publication Details

Journal
Nanoscale
Published
2025-01-01
DOI
https://doi.org/10.1039/d4nr04990j
Citations
6
Primary Topic
Graphene and Nanomaterials Applications
Type
article
Field-Weighted Citation Impact
4.04

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article

B/N-doped carbon nano-onions as nanocarriers for targeted breast cancer therapy

Ilaria Andreana, Chiara Riganti, Silvia Giordani, Hugh Mohan et al.
6 citations
Nanoscale
Graphene and Nanomaterials Applications
4.04
article

B/N-doped carbon nano-onions as nanocarriers for targeted breast cancer therapy

Ilaria Andreana, Chiara Riganti, Silvia Giordani, Hugh Mohan, Michał Bartkowski, Tania Limongi, Kevin D. Courtney, Iris C. Salaroglio, Raúl Arenal, Silvia Arpicco
article en
6 citations

Abstract

Cancer is one of the leading causes of death worldwide and represents a significant burden on global health systems. Many existing chemotherapy treatments come with severe side effects, ranging from hair loss to cardiotoxicity, and many types of cancer express chemotherapy resistance, such as triple-negative breast cancer. This study presents a novel boron/nitrogen-doped carbon nano-onion (BN-CNO) based nanocarrier system that can deliver doxorubicin (DOX) to cancer cells <i>via</i> a pH-dependent drug release mechanism. The nanocarrier formulation consists of a hyaluronic acid/phospholipid conjugate (HA-DMPE) that is non-covalently bound to the BN-CNOs upon which DOX is loaded <i>via</i> π-π stacking interactions. The HA-DMPE/BN-CNO/DOX system enhances the uptake and anticancer effects of DOX in MDA-MB-468 and MDA-MB-231 TNBC cells whilst reducing the cardiotoxicity of DOX in AC-16 human cardiomyocytes.

NanoscaleVol. 17(19)
Universidad de Zaragoza (ES), Fundacion Agencia Aragonesa para la Investigacion y el Desarrollo (ES), Instituto de Nanociencia y Materiales de Aragón (ES), Dublin City University (IE), University of Turin (IT)
European Commission, Science Foundation Ireland, Irish Research Council, Universidad de Zaragoza, Gobierno de Aragón, Agencia Estatal de Investigación
Openalex Percentile: Top 7%
Graphene and Nanomaterials Applications
4.04
DOIOpen Access PDFOpenAlex
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