The Correlation Between Il-6 Levels and Quality of Life and Depressive Syndrome in Advanced-Stage Cervical Cancer Patients at h. Adam Malik Hospital Medan - SDG

Objective: This study aims to analyze the relationship between IL-6 levels and quality of life on depressive syndrome in advanced cervical cancer patients. Theoretical Framework: Studies among cancer patients have shown an association between depression and elevated levels of pro-inflammatory cytokines. Method: This research is a correlative analytical study with a cross-sectional study approach. Sampling used non-probability sampling technique type consecutive sampling. A sample of 61 patients with advanced cervical cancer was obtained at RSUP. H. Adam Malik Medan. Results and Discussion: Data from 61 subjects with advanced cervical cancer patients showed a strong positive correlation between IL-6 and depressive syndrome as measured by PHQ-9, in which increased levels of IL-6 resulted in increased level of depressive syndrome (PHQ-9 score value), (r 0.604, p value<0.001). There is a correlation between quality of life as measured by the SF-36 and depressive syndrome in advanced cervical cancer patients. The r value in the eta correlation test between quality of life variables and depressive syndrome is 0.841. The calculated F value is 33.78 and F table is 2.37. The result indicated a correlation between quality of life and depressive syndrome in cervical cancer patients with a value of r= 0.841. Research Implications: There is a relationship between IL-6 levels and quality of life with depressive syndrome in advanced cervical cancer patients. Originality/Value: This study contributes to the literature by providing further informations regarding the relationship between IL-6 levels and quality of life, particularly in advanced cervical cancer patients with depressive syndrome.