Feasibility and Safety of Intratympanic Administration of Sustained‐Exposure Dexamethasone Thermosensitive Gel (OTO‐104) for Prevention of Cisplatin‐Induced Hearing Loss in Children: A Multisite Phase 2 Randomized Clinical Trial

Although dexamethasone at this dose was not otoprotective, these results suggest that intratympanic injection may be safe, feasible, and a viable delivery platform for testing other otoprotectants.

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Publication Details

Journal
Pediatric Blood & Cancer
Published
2025-03-24
DOI
https://doi.org/10.1002/pbc.31680
Primary Topic
Ear and Head Tumors
Type
article
Field-Weighted Citation Impact
0.00

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article

Feasibility and Safety of Intratympanic Administration of Sustained‐Exposure Dexamethasone Thermosensitive Gel (OTO‐104) for Prevention of Cisplatin‐Induced Hearing Loss in Children: A Multisite Phase 2 Randomized Clinical Trial

Debra M. Don, Robert J. Hayashi, Eli Grunstein, Daniel Choo et al.
Pediatric Blood & Cancer
Ear and Head Tumors
article

Feasibility and Safety of Intratympanic Administration of Sustained‐Exposure Dexamethasone Thermosensitive Gel (OTO‐104) for Prevention of Cisplatin‐Induced Hearing Loss in Children: A Multisite Phase 2 Randomized Clinical Trial

Debra M. Don, Robert J. Hayashi, Eli Grunstein, Daniel Choo, Etan Orgel, Kenny H. Chan, Reza Rahbar, Kay W. Chang, Matthew Sitton, Jennifer H. Foster, Judith E. C. Lieu, Allison F. O’Neill, Arun Rangaswami, James I. Geller, Brian Greffe, David R. Freyer, Timothy J. D. Ohlsen, Alice Lee, Jeffery J. Anderson
article en

Abstract

Although dexamethasone at this dose was not otoprotective, these results suggest that intratympanic injection may be safe, feasible, and a viable delivery platform for testing other otoprotectants.

Pediatric Blood & CancerVol. 72(6)
University of Southern California (US), Cincinnati Children's Hospital Medical Center (US), Boston Children's Hospital (US), Morgan Stanley Children's Hospital (US), Seattle Children's Hospital (US), Lucile Packard Children's Hospital (US), Children's Hospital of Los Angeles (US), University of California, San Francisco (US), University of Washington (US), Washington University in St. Louis (US), Children's Hospital Colorado (US), Texas Children's Hospital (US), Children's Hospital & Medical Center (US), Otonomy (United States) (US), Dana-Farber/Boston Children's Cancer and Blood Disorders Center (US), University of Colorado Denver (US), Stanford University (US)
Otonomy
Good health and well-being
Openalex Percentile: Top 92%
Ear and Head Tumors
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