The restoration of REST inhibits reactivity of Down syndrome iPSC-derived astrocytes
These findings suggest that REST is pivotal in modulating astrocyte functionality and reactivity in DS. The loss of REST in DS-astrocytes prompts the formation of reactive astrocytes, thereby compromising central nervous system homeostasis. Lithium treatment possesses the potential to rescue astrocyte reactivity in DS by restoring nucleus REST expression.
Authors
- Pike-See Cheah (ORCID: https://orcid.org/0000-0003-2181-2502)
- Sharida Fakurazi (ORCID: https://orcid.org/0000-0001-8986-876X)
- King‐Hwa Ling (ORCID: https://orcid.org/0000-0002-3968-7263)
- Tan Huang (ORCID: https://orcid.org/0000-0003-3395-9034)
Institutions
- Universiti Putra Malaysia (MY)
Publication Details
- Journal
- Frontiers in Molecular Neuroscience
- Published
- 2025-03-26
- DOI
- https://doi.org/10.3389/fnmol.2025.1552819
- Citations
- 1
- Primary Topic
- Down syndrome and intellectual disability research
- Type
- article
- Field-Weighted Citation Impact
- 1.88