Monozygotic twins discordant for juvenile dermatomyositis: clinical, serological and gene expression studies
JDM twins (and two of the non-JDM twins) had significantly lower nailfold capillary ERL and decreased serum endoglin levels compared to healthy controls. Further studies are needed to explore the role of the differentially expressed genes (DCD, KRT14, COL1A1, and COL3A1) in the pathophysiology of JDM.
Authors
- Kai Lee Yap (ORCID: https://orcid.org/0000-0003-4496-5464)
- Lauren M. Pachman (ORCID: https://orcid.org/0000-0001-8117-574X)
- Gabrielle Morgan (ORCID: https://orcid.org/0000-0002-4058-7112)
- Amer Khojah (ORCID: https://orcid.org/0000-0003-3357-4863)
- Sabah Kadri (ORCID: https://orcid.org/0000-0003-0365-6550)
- Wilfredo Marin
- Judith A. James (ORCID: https://orcid.org/0000-0002-9574-7355)
Institutions
- Northwestern University (US)
- Lurie Children's Hospital (US)
- Umm al-Qura University (SA)
- Oklahoma Medical Research Foundation (US)
Publication Details
- Journal
- Pediatric Rheumatology
- Published
- 2025-03-26
- DOI
- https://doi.org/10.1186/s12969-025-01082-7
- Primary Topic
- Inflammatory Myopathies and Dermatomyositis
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Institutes of Health