A Case Report of Successful Use of Phenytoin/Fosphenytoin in a Pediatric Kidney Transplant Recipient With Nirmatrelvir/Ritonavir‐Induced Tacrolimus Allograft Injury
To our knowledge, this is the first report of a pediatric kidney transplant patient with tacrolimus toxicity secondary to NIM-RTV therapy utilizing phenytoin/fosphenytoin to induce tacrolimus metabolism and prevent further toxicity. Heightened awareness of this interaction is paramount to reduce allograft injury and promote patient safety.
Authors
- Lauren Galea
- Rachel Finkel
- Benjamin L. Laskin (ORCID: https://orcid.org/0000-0002-9994-8509)
- Jonathan D. Savant
- Kevin J. Downes (ORCID: https://orcid.org/0000-0001-5015-8146)
- Jennifer Hewlett
- Christopher LaRosa
- Sandra Amaral (ORCID: https://orcid.org/0000-0001-7357-242X)
- Selasie Goka
- Bernarda Viteri (ORCID: https://orcid.org/0000-0001-5566-0768)
- Sonya Lopez
- Uche Nwaogazie
Institutions
- Children's Hospital of Philadelphia (US)
- University of Pennsylvania (US)
Publication Details
- Journal
- Pediatric Transplantation
- Published
- 2025-03-26
- DOI
- https://doi.org/10.1111/petr.70030
- Primary Topic
- Renal Transplantation Outcomes and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00