Exploring the possible mechanism of low-dose naloxone exposure improving the immune microenvironment of gastric cancer tumors
LDN improved the ability of CD8<sup>+</sup>T cells to kill gastric cancer cells and reduced CD8<sup>+</sup>T cell exhaustion. The mechanism underlying these LDN-mediated phenomena may involve regulation of immune checkpoint expression in CD8<sup>+</sup> T cells, increased cytotoxic factor secretion by CD8<sup>+</sup> T cells via the TLR4/AKT/mTOR pathway, or regulation of expression of opioid receptors on CD8<sup>+</sup>T cells, thereby further affecting CD8<sup>+</sup>T cell exhaustion.
Authors
- Xiangzhen Min
- Mingyue Lv (ORCID: https://orcid.org/0000-0002-9868-6340)
- Xiaoyong Zhao
- Yufang Leng (ORCID: https://orcid.org/0000-0001-7094-2413)
- Renjun Lv (ORCID: https://orcid.org/0000-0002-6530-8386)
- Xiaoxi Li (ORCID: https://orcid.org/0009-0000-7066-7810)
- Yan Ma
Institutions
- Shandong University of Traditional Chinese Medicine (CN)
- Shandong Tumor Hospital (CN)
- Affiliated Hospital of Shandong University of Traditional Chinese Medicine (CN)
- Shandong First Medical University (CN)
- First Hospital of Lanzhou University (CN)
- Lanzhou University (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-03-26
- DOI
- https://doi.org/10.3389/fimmu.2025.1524930
- Primary Topic
- Cancer, Stress, Anesthesia, and Immune Response
- Type
- article
- Field-Weighted Citation Impact
- 0.00