Two-injection start regimen of long-acting aripiprazole in three patients treated with bipolar affective disorder manic episodes: Review with case reports

Long-acting aripiprazole is used in the acute treatment of bipolar affective disorder (BAD) and schizophrenia as well as in maintenance treatment.There are few data on the use of long-acting aripiprazole initial double dose in BAD.Factors such as frequent hospitalizations, recurrent attacks, aggression, comorbid substance use, lack of insight, and poor medication compliance are influental in the choice of long-acting antipsychotics.Aripiprazole initial double dose may be a safe and effective option in patients with BAD.In this study, we will present 3 cases who were involuntarily hospitalized with BAD manic episode and treated with long-acting aripiprazole two-injection start regimen and review the literature on this subject.