Genetic analysis reveals the shared genetic architecture between breast cancer and atrial fibrillation
This study systematically investigated the shared genetic overlap between AF and BC. Several pleiotropic SNPs and genes were identified, and co-enriched tissue and cell types were revealed. The findings highlight common mechanisms from a genetic perspective rather than a causal relationship. This study provides new insights into the AF-BC association and suggests potential experimental targets and directions for future research. Additionally, the results underscore the importance of monitoring the potential risk of one disease in patients diagnosed with the other.
Authors
- Jiayi Chen (ORCID: https://orcid.org/0009-0008-9762-5133)
- Fuhong Gong
- Ruimin Liu (ORCID: https://orcid.org/0000-0003-3690-4178)
- Yang Yang (ORCID: https://orcid.org/0000-0002-3842-4744)
- Wenlin Chen (ORCID: https://orcid.org/0000-0001-8986-4064)
- Mengping Lin
- Xiaohua Zhao (ORCID: https://orcid.org/0000-0002-0998-4136)
- Fei Ge (ORCID: https://orcid.org/0000-0002-2319-3904)
- Jingge Miao
Institutions
- Peking University (CN)
- Kunming Medical University (CN)
- Peking University Cancer Hospital (CN)
- First Affiliated Hospital of Kunming Medical University (CN)
- Yan'an Hospital Affiliated To Kunming Medical University (CN)
Publication Details
- Journal
- Frontiers in Genetics
- Published
- 2025-03-25
- DOI
- https://doi.org/10.3389/fgene.2025.1450259
- Citations
- 1
- Primary Topic
- Genetic Associations and Epidemiology
- Type
- article
- Field-Weighted Citation Impact
- 1.82