Histone demethylase KDM6B promotes glioma cell proliferation by increasing <i>PDGFRA</i> expression via chromatin loop formation
This study reveals a new epigenetic mechanism of <i>PDGFRA</i> overexpression in glioma cells, that is, KDM6B catalyzes the demethylation of H3K27me3 and induces chromatin loop formation to activate <i>PDGFRA</i> expression. This study is of great significance for the understanding of glioma development and the application of new treatment strategies, such as radiation therapy combined with epigenetic therapy.
Authors
- Xiaoqiang Guo (ORCID: https://orcid.org/0000-0002-1068-5926)
- Aixia Sui (ORCID: https://orcid.org/0000-0002-2992-9820)
Institutions
- Hebei General Hospital (CN)
- Shenyang Sport University (CN)
Publication Details
- Journal
- Neurological Research
- Published
- 2025-03-25
- DOI
- https://doi.org/10.1080/01616412.2025.2480326
- Citations
- 1
- Primary Topic
- Epigenetics and DNA Methylation
- Type
- article
- Field-Weighted Citation Impact
- 0.81
Funders
- Natural Science Foundation of Hebei Province