Correlation of Paraoxonas1/Arylesterase Enzyme Activity with Microalbuminuria in Type 2 Diabetes Mellitus

Objective:The aim of this study is to investigate the relationship between paraoxonase 1/ arylesterase activity which have antioxidant properties and microalbuminuria in patients with type 2 diabetic. Methods:The study included 48 patients (24 women and 24 men) with type 2 diabetes mellitus and microalbuminuria and 17 healthy volunteers as the control group (8 women and 9 men).Demographic data of the patients (age, gender, chronic disease); height-weight-body mass index (BMI), waist circumference, systolic and diastolic blood pressure and biochemical tests, fasting blood glucose (FBG), HbA1c, total cholesterol, triglyceride, LDL, HDL, CRP, urea, creatinine levels and spot urine albumin/creatinine ratios were recorded.In addition, serum paraoxonase (PON) and arylesterase (ARE) levels were studied.Results: PON and ARE levels were found to be significantly lower in the type 2 diabetes with microalbuminuria (p<0.05).No statistically significant correlation was detected between ARE and PON and other parameters in the patient group (Spearman Correlation Analysis).Based on the ROC curve analysis, the laboratory cut-point used to obtain the best predictive results for differentiating the diabetic patients from the controls was PON 8.85 U/mL (sensitivity 95.83; specificity 47.06) and ARE 5.47 ng/mL (sensitivity 93.75; specificity 47.06). Conclusion:PON and ARE levels were found to be significantly lower in type 2 diabetes mellitus patients with microalbuminuria, and there was no relationship between PON1/ARE activity and microalbuminuria.