Low natalizumab trough concentrations are associated with reduced seroconversion of the John Cunningham virus in natalizumab-treated patients with multiple sclerosis
The seroconversion rate observed in patients with MS with low trough concentrations was substantially lower compared with those with high trough concentrations during natalizumab treatment. This emphasises the importance of personalised EID, where intervals between infusions are prolonged to achieve lower natalizumab trough concentrations, to increase drug safety.
Authors
- Beatrijs Wokke (ORCID: https://orcid.org/0000-0002-2616-8464)
- Floris C. Loeff (ORCID: https://orcid.org/0000-0001-7059-2038)
- Jop Mostert (ORCID: https://orcid.org/0000-0003-3640-9935)
- Bernard M.J. Uitdehaag (ORCID: https://orcid.org/0000-0002-9226-7364)
- Alyssa A Toorop (ORCID: https://orcid.org/0000-0002-7196-9826)
- Liza M. Y. Gelissen (ORCID: https://orcid.org/0009-0004-4864-1429)
- Esther Zeinstra (ORCID: https://orcid.org/0000-0002-2777-2313)
- Willem H. Bouvy
- Eva M. M. Strijbis (ORCID: https://orcid.org/0000-0001-6705-5864)
- Mark E Kloosterziel
- Zoé L. E. van Kempen (ORCID: https://orcid.org/0000-0001-9557-5381)
- Christiaan M Roosendaal (ORCID: https://orcid.org/0000-0001-7998-5225)
- Birgit I. Lissenberg‐Witte (ORCID: https://orcid.org/0000-0001-9448-1826)
- Caspar E.P. van Munster (ORCID: https://orcid.org/0000-0001-8701-5413)
- Theo Rispens (ORCID: https://orcid.org/0000-0001-9600-1312)
- Bob W. van Oosten (ORCID: https://orcid.org/0000-0003-4536-6201)
- M. Eurelings
- Elske Hoitsma
- Anke Vennegoor
- Brigit A. de Jong (ORCID: https://orcid.org/0000-0002-7005-7008)
- Nynke F. Kalkers (ORCID: https://orcid.org/0000-0001-6420-7914)
- Joep Killestein (ORCID: https://orcid.org/0000-0002-6347-5957)
- Jessie van Genugten
- Luuk C van Rooij
- Jeroen van Eijk
- Edo P. J. Arnoldus (ORCID: https://orcid.org/0000-0002-5944-5931)
- P Schipper (ORCID: https://orcid.org/0009-0008-2402-0897)
- Jessica Nielsen
- L. G. F. Sinnige
- E.L.J. Hoogervorst
- Jolijn J Kragt
Institutions
- Erasmus MC (NL)
- Medisch Centrum Leeuwarden (NL)
- Sanquin (NL)
- Goudappel Coffeng (NL)
- Slingeland Ziekenhuis (NL)
- Reinier de Graaf Hospital (NL)
- Alrijne Ziekenhuis (NL)
- St. Antonius Ziekenhuis (NL)
- OLVG (NL)
- Amphia Ziekenhuis (NL)
- Diakonessenhuis hospital (NL)
- Maasstad Ziekenhuis (NL)
- Canisius-Wilhelmina Ziekenhuis (NL)
- Flevoziekenhuis (NL)
- Isala (NL)
- Elisabeth-TweeSteden Ziekenhuis (NL)
- Ziekenhuis Groep Twente (NL)
- Amsterdam University Medical Centers (NL)
- Rijnstate Hospital (NL)
- Jeroen Bosch Ziekenhuis (NL)
- Spaarne Gasthuis (NL)
- Vrije Universiteit Amsterdam (NL)
- University of Amsterdam (NL)
- Erasmus University Rotterdam (NL)
Publication Details
- Journal
- Journal of Neurology Neurosurgery & Psychiatry
- Published
- 2025-03-25
- DOI
- https://doi.org/10.1136/jnnp-2024-335761
- Citations
- 1
- Primary Topic
- Polyomavirus and related diseases
- Type
- article
- Field-Weighted Citation Impact
- 1.05