Diagnostic value of metagenomic next-generation sequencing in detecting Pneumocystis jirovecii pneumonia in HIV-infected patients
mNGS offers superior specificity, accuracy, and co-infection detection compared to traditional methods. Its high NPV (100%) supports clinical utility in ruling out PJP. While resource-intensive, mNGS is a promising first-line diagnostic tool for HIV-associated PJP, particularly in polymicrobial infection settings.
Authors
- He Jia-Wen
- Zhengchen Jiang (ORCID: https://orcid.org/0000-0003-4765-8830)
- Meng Tang (ORCID: https://orcid.org/0000-0003-0561-2906)
- Mingli Zhu (ORCID: https://orcid.org/0000-0002-6758-2274)
- Yuan-Ting Wu (ORCID: https://orcid.org/0000-0002-8142-087X)
- Yang Li (ORCID: https://orcid.org/0000-0002-1656-0198)
- Feng Li (ORCID: https://orcid.org/0000-0002-0296-9267)
- Ying Chen (ORCID: https://orcid.org/0000-0003-0582-380X)
- Meihua Wang (ORCID: https://orcid.org/0000-0002-8860-3329)
- Zhibo Xu
Institutions
- Zhejiang Chinese Medical University (CN)
- Hangzhou Xixi hospital (CN)
Publication Details
- Journal
- Frontiers in Medicine
- Published
- 2025-03-26
- DOI
- https://doi.org/10.3389/fmed.2025.1567484
- Primary Topic
- Pneumocystis jirovecii pneumonia detection and treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00