Evaluation of hematologic inflammation parameters and cranial magnetic resonance imaging findings in patients with trigeminal neuralgia

Aims: This study aimed to evaluate the relationship between trigeminal neuralgia (TN) and hematological parameters, including leukocyte-based inflammatory indices, and to explore their association with cranial magnetic resonance imaging (MRI) findings. Methods: A retrospective analysis was conducted on 114 patients with newly diagnosed TN and 114 healthy control groups with comparable demographic characteristics. Clinical, laboratory, and cranial MRI data were collected from hospital records. White matter abnormalities were identified via cranial MRI, and inflammatory indices were calculated as follows: neutrophil-to-lymphocyte ratio (NLR)=Neutrophil count/lymphocyte count, platelet-to-lymphocyte ratio (PLR)=Platelet count/lymphocyte count, Systemic Immune-Inflammation Index (SII)=Platelet count×neutrophil count/lymphocyte count, and Systemic Inflammatory Response Index (SIRI)=Neutrophil count×monocyte count/lymphocyte count. Results: TN patients showed significantly higher leukocyte counts (7.4±1.8 vs. 6.0±1.9 ×10³/μl, p