The LRRK2 p.L1795F variant causes Parkinson’s disease in the European population
LRRK2-PD represents the most common form of autosomal dominant Parkinson's disease. We identified the LRRK2 p.L1795F variant in three families and six additional unrelated cases using genetic data from over 50,000 individuals. Carriers with available genotyping data shared a common haplotype. The clinical presentation resembles other LRRK2-PD forms. Combined with published functional evidence showing strongly enhanced LRRK2 kinase activity, we provide evidence that LRRK2 p.L1795F is pathogenic.
Authors
- Mario Cornejo‐Olivas (ORCID: https://orcid.org/0000-0001-6313-5680)
- Patrick A. Lewis (ORCID: https://orcid.org/0000-0003-4537-0489)
- Gonzálo Arboleda (ORCID: https://orcid.org/0000-0003-1781-939X)
- Jorge Orozco (ORCID: https://orcid.org/0000-0001-6598-1880)
- Vítor Tumas (ORCID: https://orcid.org/0000-0003-2402-2709)
- A. Nazlı Başak (ORCID: https://orcid.org/0000-0001-6977-2517)
- Roger L. Albin (ORCID: https://orcid.org/0000-0002-0629-608X)
- Joshua M Shulman (ORCID: https://orcid.org/0000-0002-1835-1971)
- Andrea Quattrone (ORCID: https://orcid.org/0000-0003-2071-2083)
- Jean‐Christophe Corvol (ORCID: https://orcid.org/0000-0001-7325-0199)
- Germaine Hiu-Fai Chan
- Cabell Jonas
- Anastasia Illarionova (ORCID: https://orcid.org/0000-0002-1711-7155)
- Katja Lohmann (ORCID: https://orcid.org/0000-0002-5121-1460)
- Kajsa Brolin (ORCID: https://orcid.org/0000-0003-4832-922X)
- Ignacio Álvarez (ORCID: https://orcid.org/0000-0002-8537-3935)
- Joanne Trinh (ORCID: https://orcid.org/0000-0001-9863-2070)
- Claire E. Shepherd (ORCID: https://orcid.org/0000-0002-0399-3218)
- Megan J. Puckelwartz (ORCID: https://orcid.org/0000-0002-0455-2983)
- Honglei Chen (ORCID: https://orcid.org/0000-0003-3446-7779)
- J Solle (ORCID: https://orcid.org/0000-0002-9941-4830)
- Geidy E. Serrano
- Prashanth Lingappa Kukkle (ORCID: https://orcid.org/0000-0002-4610-947X)
- Christiane Zweier (ORCID: https://orcid.org/0000-0001-8002-2020)
- Johanna Junker (ORCID: https://orcid.org/0000-0003-0756-9569)
- Steven Lubbe (ORCID: https://orcid.org/0000-0002-7103-6671)
- Nobutaka Hattori (ORCID: https://orcid.org/0000-0002-2034-2556)
- Zaruhi Tavadyan
- Georgia Xiromerisiou (ORCID: https://orcid.org/0000-0001-7162-3588)
- Sarah Camargos (ORCID: https://orcid.org/0000-0001-9829-6783)
- Grazia Annesi (ORCID: https://orcid.org/0000-0001-9951-8798)
- Seth Love (ORCID: https://orcid.org/0000-0001-8683-3625)
- Kristin Levine (ORCID: https://orcid.org/0000-0002-5702-0980)
- Miguel E. Rentería (ORCID: https://orcid.org/0000-0003-4626-7248)
- Manabu Funayama (ORCID: https://orcid.org/0000-0002-7412-3631)
- Sergiu Groppa (ORCID: https://orcid.org/0000-0002-2551-5655)
- Franziska Hopfner (ORCID: https://orcid.org/0000-0001-6524-0281)
- Lucilla Parnetti (ORCID: https://orcid.org/0000-0001-5722-3967)
- Walaa A. Kamel (ORCID: https://orcid.org/0000-0002-3363-0370)
- Shahrul Azmin
- Gulnaz Kaishibayeva
- Janet Hoenicka (ORCID: https://orcid.org/0000-0002-6790-6988)
- John Hardy (ORCID: https://orcid.org/0000-0002-3122-0423)
- Nazish Rafique (ORCID: https://orcid.org/0000-0002-1565-415X)
- Xiaopu Zhou (ORCID: https://orcid.org/0000-0001-5307-5805)
- Zih‐Hua Fang (ORCID: https://orcid.org/0000-0002-0225-8772)
- Ana Westenberger (ORCID: https://orcid.org/0000-0001-8062-6959)
- Ruey‐Meei Wu (ORCID: https://orcid.org/0000-0002-4947-5467)
- Olaitan Okunoye
- Mayela Rodríguez‐Violante (ORCID: https://orcid.org/0000-0002-6041-9941)
- Pau Pástor (ORCID: https://orcid.org/0000-0002-7493-8777)
- Alexis Brice (ORCID: https://orcid.org/0000-0002-0941-3990)
- Alexander Zimprich (ORCID: https://orcid.org/0000-0002-1668-5177)
- Phillip Chan (ORCID: https://orcid.org/0000-0002-4071-4409)
- Masharip Atadzhanov (ORCID: https://orcid.org/0000-0003-3708-8141)
- M. Leonor Bustamante (ORCID: https://orcid.org/0000-0001-9071-2463)
- Roopa Rajan (ORCID: https://orcid.org/0000-0003-4987-7252)
- Katerina Markopoulou (ORCID: https://orcid.org/0000-0003-3973-5437)
- Edward A. Fon (ORCID: https://orcid.org/0000-0002-5520-6239)
- Alex Medina (ORCID: https://orcid.org/0000-0001-8640-3967)
- Hampton L. Leonard (ORCID: https://orcid.org/0000-0003-2390-8110)
- Chin‐Hsien Lin (ORCID: https://orcid.org/0000-0001-8566-7573)
- Bradford Casey (ORCID: https://orcid.org/0000-0002-2623-5997)
- Paula Saffie Awad (ORCID: https://orcid.org/0000-0002-8056-365X)
- Marlene Jiménez-Del-Río (ORCID: https://orcid.org/0000-0003-3477-2386)
- Jonathan Ambrose Carr (ORCID: https://orcid.org/0000-0002-7677-426X)
- Oury Monchi (ORCID: https://orcid.org/0000-0003-2148-5409)
- Carlos Cruchaga (ORCID: https://orcid.org/0000-0002-5261-689X)
- Roy N. Alcalay (ORCID: https://orcid.org/0000-0002-5717-4875)
- Jia Nee Foo (ORCID: https://orcid.org/0000-0001-9899-2308)
- Claire Wegel
- Marcelo Kauffman (ORCID: https://orcid.org/0000-0003-1680-5092)
- Christine Klein
- Nancy Y. Ip (ORCID: https://orcid.org/0000-0002-2763-8907)
- Brian K. Fiske (ORCID: https://orcid.org/0000-0002-8797-2042)
- Wael Mohamed
- Lauren Ruffrage
- Manu Sharma (ORCID: https://orcid.org/0000-0001-7394-2419)
- Mike A. Nalls (ORCID: https://orcid.org/0000-0003-0319-4325)
- Alberto J. Espay (ORCID: https://orcid.org/0000-0002-3389-136X)
- Ignacio Fernandez Mata (ORCID: https://orcid.org/0000-0003-1198-0633)
- Tim Anderson (ORCID: https://orcid.org/0000-0002-1116-3839)
- Jan Olav Aasly (ORCID: https://orcid.org/0000-0002-0558-7686)
- Sara Bandrés‐Ciga (ORCID: https://orcid.org/0000-0003-0056-1361)
- Lisa Shulman (ORCID: https://orcid.org/0000-0001-9832-1897)
- Mathew J. Koretsky (ORCID: https://orcid.org/0000-0003-4341-3991)
- Paula Reyes‐Pérez (ORCID: https://orcid.org/0000-0001-8062-7441)
- Raymond L. Rosales (ORCID: https://orcid.org/0000-0001-6387-1389)
- Norlinah Mohamed Ibrahim (ORCID: https://orcid.org/0000-0002-6684-7488)
- Pedro Chaná
- Mary B. Makarious (ORCID: https://orcid.org/0000-0002-7978-1051)
- Sulev Kõks
- Ángel Viñuela
- Manuela Tan (ORCID: https://orcid.org/0000-0001-5835-669X)
- Andrew K. Sobering (ORCID: https://orcid.org/0000-0002-9251-2614)
- Patricio Olguı́n (ORCID: https://orcid.org/0000-0002-8847-4969)
- Katherine M. Andersh (ORCID: https://orcid.org/0000-0001-7709-4111)
- Lara Mariah Lange (ORCID: https://orcid.org/0000-0002-7162-9821)
- Tatiana Foroud
- Niccolò Emanuele Mencacci (ORCID: https://orcid.org/0000-0003-3383-9665)
- Eng‐King Tan (ORCID: https://orcid.org/0000-0003-2977-9743)
- Susan Helen Fox (ORCID: https://orcid.org/0009-0004-7568-1645)
- Karen Nuytemans (ORCID: https://orcid.org/0000-0003-2670-4914)
- Sonya B. Dumanis (ORCID: https://orcid.org/0000-0002-3345-9497)
- Matthew James Farrer (ORCID: https://orcid.org/0000-0003-1159-5321)
- Shen‐Yang Lim (ORCID: https://orcid.org/0000-0002-6942-2522)
- Alastair John Noyce (ORCID: https://orcid.org/0000-0003-3027-5497)
- Ferzana Amod (ORCID: https://orcid.org/0000-0003-4545-8704)
- Luca Marsili (ORCID: https://orcid.org/0000-0002-6438-9911)
- Alvaro Hernández‐Flores (ORCID: https://orcid.org/0000-0003-1900-9868)
- Oluwadamilola O. Ojo (ORCID: https://orcid.org/0000-0001-6461-2653)
- Sumit Dey
- Soraya Bardien (ORCID: https://orcid.org/0000-0002-3508-3438)
- Stewart A. Factor (ORCID: https://orcid.org/0000-0002-0449-973X)
- Artur Francisco Schumacher Schuh (ORCID: https://orcid.org/0000-0002-8722-0908)
- Tommaso Schirinzi (ORCID: https://orcid.org/0000-0002-2517-6278)
- Faraz Faghri (ORCID: https://orcid.org/0000-0001-5744-8728)
- Alejandro Martínez-Carrasco (ORCID: https://orcid.org/0000-0001-6191-1703)
- Samson Khachatryan (ORCID: https://orcid.org/0000-0002-3098-2135)
- Jared Williamson
- Yun Joong Kim (ORCID: https://orcid.org/0000-0002-2956-1552)
- Anthony H.V. Schapira (ORCID: https://orcid.org/0000-0002-3018-3966)
- Donald G. Grosset (ORCID: https://orcid.org/0000-0002-2757-8203)
- Cholpon Shambetova (ORCID: https://orcid.org/0000-0002-2547-315X)
- Nor Azian Abdul Murad (ORCID: https://orcid.org/0000-0002-6124-5517)
- Ekemini Riley
- Lasse Pihlstrøm (ORCID: https://orcid.org/0000-0002-7635-8645)
- Daniel Martínez-Ramírez (ORCID: https://orcid.org/0000-0001-8003-0610)
- María Stamelou (ORCID: https://orcid.org/0000-0003-1668-9925)
- Yih‐Ru Wu (ORCID: https://orcid.org/0000-0003-1191-2542)
- Eleanor J. Stafford (ORCID: https://orcid.org/0000-0003-2451-4308)
- Marissa Dean (ORCID: https://orcid.org/0000-0002-9318-769X)
- Yi Wen Tay (ORCID: https://orcid.org/0000-0002-9319-0768)
- Carlos Roberto de Mello Rieder (ORCID: https://orcid.org/0000-0003-2950-7211)
- Nicholas William Wood (ORCID: https://orcid.org/0000-0002-9500-3348)
- Altynay Karimova (ORCID: https://orcid.org/0000-0002-6249-1998)
- Toni L. Pitcher (ORCID: https://orcid.org/0000-0003-4661-5038)
- Bayasgalan Tserensodnom
- Gerd Tinkhauser (ORCID: https://orcid.org/0000-0002-1954-1873)
- Thomas Gasser (ORCID: https://orcid.org/0000-0002-1069-1146)
- Enza Maria Valente (ORCID: https://orcid.org/0000-0002-0600-6820)
- Albert Kwaku Akpalu (ORCID: https://orcid.org/0000-0002-4802-9852)
- Ai Huey Tan (ORCID: https://orcid.org/0000-0002-2979-3839)
- Günter U. Höglinger (ORCID: https://orcid.org/0000-0001-7587-6187)
- Ioannis Tarnanas (ORCID: https://orcid.org/0000-0003-4069-6551)
- Tomotaka Shiraishi (ORCID: https://orcid.org/0000-0002-0916-5800)
- Nelson Yuk-Fai Cheung
- Bashayer Al Mubarak
- Rim Amouri (ORCID: https://orcid.org/0000-0001-5641-5748)
- Connie Marras (ORCID: https://orcid.org/0000-0002-9236-9328)
- Monica Gagliardi (ORCID: https://orcid.org/0000-0002-3386-9808)
- Yared Zenebe Zewde (ORCID: https://orcid.org/0000-0002-6442-7148)
- Bernadette Siddiqi
- Ignacio Juan Keller Sarmiento (ORCID: https://orcid.org/0000-0003-0979-6001)
- Anette E. Schrag (ORCID: https://orcid.org/0000-0002-9872-6680)
- Cornelis Blauwendraat (ORCID: https://orcid.org/0000-0001-9358-8111)
- Mie Rizig (ORCID: https://orcid.org/0000-0003-2420-4449)
- Tao Xie (ORCID: https://orcid.org/0000-0001-9551-6613)
- Ioannis Dagklis
- Jifeng Guo (ORCID: https://orcid.org/0000-0002-3658-3928)
- Mohamed Salama (ORCID: https://orcid.org/0000-0003-1644-0273)
- Simon Stott (ORCID: https://orcid.org/0000-0002-5741-4664)
- Kamalini Ghosh Galvelis (ORCID: https://orcid.org/0009-0000-4178-0777)
- Laura Ibáñez (ORCID: https://orcid.org/0000-0003-2381-7059)
- Sarah El-Sadig
- Melina Ellis (ORCID: https://orcid.org/0000-0002-8542-048X)
- Rimona Sharon Weil (ORCID: https://orcid.org/0000-0002-5092-6325)
- Mehri Salari
- Kishore Raj Kumar (ORCID: https://orcid.org/0000-0003-3482-6962)
- Peter O. Bauer (ORCID: https://orcid.org/0000-0003-2811-1354)
- Rajeev Ojha (ORCID: https://orcid.org/0000-0001-7680-7036)
- Sohini Chowdhury (ORCID: https://orcid.org/0009-0009-8321-0081)
- Samia Ben Sassi (ORCID: https://orcid.org/0000-0002-1002-5979)
- Njideka Ulunma Okubadejo (ORCID: https://orcid.org/0000-0003-2975-8803)
- Brit Mollenhauer (ORCID: https://orcid.org/0000-0001-8437-3645)
- Huw R. Morris (ORCID: https://orcid.org/0000-0002-5473-3774)
- Henry Houlden (ORCID: https://orcid.org/0000-0002-2866-7777)
- Wei Luo (ORCID: https://orcid.org/0000-0001-6951-7698)
- Miguel Inca‐Martinez (ORCID: https://orcid.org/0000-0003-3770-0476)
- Caroline B. Pantazis
- Gençer Genç (ORCID: https://orcid.org/0000-0002-8094-3062)
- María Teresa Periñán (ORCID: https://orcid.org/0000-0001-7412-7440)
- Kin Ying Mok (ORCID: https://orcid.org/0000-0003-3145-880X)
- Dan Vitale (ORCID: https://orcid.org/0000-0002-0637-3671)
- Joseph Jankovic
- Huifang Shang (ORCID: https://orcid.org/0000-0003-0947-1151)
- Maria Leila M. Doquenia (ORCID: https://orcid.org/0000-0003-3708-6680)
- Beisha Tang (ORCID: https://orcid.org/0000-0003-2120-1576)
- Christian Beetz (ORCID: https://orcid.org/0000-0001-7061-2895)
- Harutyun Madoev (ORCID: https://orcid.org/0000-0001-5360-5319)
- Özgür Öztop Çakmak (ORCID: https://orcid.org/0000-0003-3413-0332)
- Vida Obese (ORCID: https://orcid.org/0000-0002-1037-0510)
- Е. А. Яковенко
- Eva‐Juliane Vollstedt (ORCID: https://orcid.org/0000-0002-6898-9201)
- Todd Sherer (ORCID: https://orcid.org/0000-0001-9667-6600)
- Leonidas Stefanis (ORCID: https://orcid.org/0000-0003-3569-8990)
- Pin‐Jui Kung (ORCID: https://orcid.org/0000-0001-8369-0227)
- Azlina Ahmad‐Annuar (ORCID: https://orcid.org/0000-0001-6329-4366)
- Hirotaka Iwaki (ORCID: https://orcid.org/0000-0002-8982-7885)
- Emilia Mabel Gatto (ORCID: https://orcid.org/0000-0002-1346-5443)
- Micol Avenali (ORCID: https://orcid.org/0000-0002-7880-9921)
- Maggie Kuhl (ORCID: https://orcid.org/0009-0009-3187-4572)
- Benjamin Pizarro Galleguillos
- Charisse Comart
- Efthymios Dadiotis
- Georgios Hadjigorgiou
- Naomi Louie (ORCID: https://orcid.org/0009-0001-1104-8742)
- Shoaib Ur-Rehman
- Ted Fon
- Ejaz Shiamim
- Andrew B. Singleton (ORCID: https://orcid.org/0000-0001-5606-700X)
- Muhammad Umair (ORCID: https://orcid.org/0000-0001-6729-9746)
- Deborah A. Hall (ORCID: https://orcid.org/0000-0003-2772-7851)
- Hsiu-Chuan Wu
- Yeajin Song
- Nicole Kuznetsov (ORCID: https://orcid.org/0009-0005-9847-0282)
- Jessica Martin (ORCID: https://orcid.org/0009-0000-0830-9289)
- Lenora A. Higginbotham
- Dena G. Hernandez
- Kaileigh Murphy
- Marcelo Miranda (ORCID: https://orcid.org/0009-0001-0974-4757)
- Julie Hunter
- Arinola Sanyaolu
- Rauan Kaiyrzhanov
- Nigel Williams
- Camille Carroll
- Paul Krack
- Simona Jasaityte (ORCID: https://orcid.org/0009-0009-6030-2901)
- Esther Cubo
- Thomas Beach
- Laurel Screven (ORCID: https://orcid.org/0000-0002-1330-7779)
- Lana M. Chahine
- Sibel Ertan
- Divya KP
- Ruth Walker
- Karl Kieburtz
- Pramod Pal (ORCID: https://orcid.org/0000-0002-0669-7385)
- Katrin Beyer
- Claire Bale
- Kenneth Marek
- Rupam Borgohain (ORCID: https://orcid.org/0000-0001-6734-3305)
- Jonggeol Jeff Kim
- Duan Nguyen
- Alyssa O’Grady
- Beomseok Jeon
- Toan Nguyen
- Piu Chan
- Rejko Krüger (ORCID: https://orcid.org/0000-0003-4258-6241)
- Asha Kishore (ORCID: https://orcid.org/0000-0003-3292-1544)
Institutions
- Universidade Federal de Minas Gerais (BR)
- Northwestern University (US)
- Beni-Suef University (EG)
- Jikei University School of Medicine (JP)
- University of Rome Tor Vergata (IT)
- University of Bern (CH)
- University of London (GB)
- Kyrgyz State Medical Academy (KG)
- University of Maryland, Baltimore (US)
- Oslo University Hospital (NO)
- Montreal Neurological Institute and Hospital (CA)
- National Institutes of Health (US)
- Universidade Federal do Rio Grande do Sul (BR)
- Alion Science and Technology (United States) (US)
- Beth Israel Deaconess Medical Center (US)
- Cleveland Clinic (US)
- University Health Network (CA)
- Royal Veterinary College (GB)
- NorthShore University HealthSystem (US)
- Kaiser Permanente (US)
- Universidade Federal de Ciências da Saúde de Porto Alegre (BR)
- Koç University (TR)
- Garvan Institute of Medical Research (AU)
- University of Ghana (GH)
- Central South University (CN)
- Nizam's Institute of Medical Sciences (IN)
- University of Miami (US)
- University of Thessaly (GR)
- University of Khartoum (SD)
- Emory University (US)
- Tribhuvan University (NP)
- University of Georgia (US)
- Queen Mary University of London (GB)
- National Taiwan University (TW)
- University of Pittsburgh (US)
- Nanyang Technological University (SG)
- Murdoch University (AU)
- Universidade de São Paulo (BR)
- Baylor College of Medicine (US)
- Capital Medical University (CN)
- University of Toronto (CA)
- University of Luxembourg (LU)
- Lund University (SE)
- Ionian University (GR)
- Johannes Gutenberg University Mainz (DE)
- University of Lagos (NG)
- University of Puerto Rico System (PR)
- Hong Kong University of Science and Technology (HK)
- Washington University in St. Louis (US)
- Norwegian University of Science and Technology (NO)
- Fundación Chile (CL)
- Aristotle University of Thessaloniki (GR)
- QIMR Berghofer Medical Research Institute (AU)
- Sichuan University (CN)
- University of Pavia (IT)
- Stellenbosch University (ZA)
- Universidad Científica del Sur (PE)
- University of Perugia (IT)
- University of Michigan (US)
- Toronto Western Hospital (CA)
- Severance Hospital (KR)
- Concord Repatriation General Hospital (AU)
- Sree Chitra Thirunal Institute for Medical Sciences and Technology (IN)
- King Faisal Specialist Hospital & Research Centre (SA)
- University Hospital of Bern (CH)
- German Center for Neurodegenerative Diseases (DE)
- University Kebangsaan Malaysia Medical Centre (MY)
- Banner Health (US)
- Michael J. Fox Foundation (US)
- Seoul National University Hospital (KR)
- LMU Klinikum (DE)
- Universidad de Costa Rica (CR)
- University of Alabama at Birmingham (US)
- University of Florida (US)
- University of Zambia (ZM)
- University of Malaya (MY)
- Universidad de Antioquia (CO)
- University of Bristol (GB)
- Universidad Nacional de Colombia (CO)
- Magna Graecia University (IT)
- University of Illinois Chicago (US)
- Sorbonne Université (FR)
- University of Chicago (US)
- International Islamic University Malaysia (MY)
- Augusta University Health (US)
- Align Technology (United States) (US)
- West China Hospital of Sichuan University (CN)
- Institute for Integrative and Experimental Genomics (DE)
- Mongolian National University of Medical Sciences (MN)
- Biomedical Research Foundation of the Academy of Athens (GR)
- Taoyuan Chang Gung Memorial Hospital (TW)
- Parkinson Research Foundation (US)
- Hue University (VN)
- King Abdullah International Medical Research Center (SA)
- University Hospital Mútua de Terrassa (ES)
- Hospital de Clínicas de Porto Alegre (BR)
- Fundación Valle del Lili (CO)
- Parkinson's UK (GB)
- Hospital Ramos Mejía (AR)
- National Institute of Neurological Disorders and Stroke (US)
- Institute for Neurodegenerative Disorders (US)
- University Hospital Schleswig-Holstein (DE)
- Hospital Universitario de Burgos (ES)
- James J. Peters VA Medical Center (US)
- Universitätsmedizin Göttingen (DE)
- Indiana University Bloomington (US)
- Universidad Metropolitana de Honduras (HN)
- Hygeia Hospital (GR)
- Institut Universitaire de Gériatrie de Montréal (CA)
- Mútua Terrassa (ES)
- National Neuroscience Institute (SG)
- Colorado Permanente Medical Group (US)
- National Taiwan University Hospital (TW)
- Instituto de Biomedicina de Sevilla (ES)
- National Institute on Aging (US)
- Institut d'Investigació en Ciències de la Salut Germans Trias i Pujol (ES)
- Centogene (Germany) (DE)
- Hospital de Niños de la Santísima Trinidad (AR)
- Juntendo University Hospital (JP)
- Banner Sun Health Research Institute (US)
- Instituto Nacional de Neurología y Neurocirugía (MX)
- Aster Medcity (IN)
- National Hospital for Neurology and Neurosurgery (GB)
- Anzac Research Institute (AU)
- Hospital Universitari Germans Trias i Pujol (ES)
- University of Science and Technology Bannu (PK)
- National Research Council (IT)
- Şişli Etfal Eğitim ve Araştırma Hastanesi (TR)
- National Institute of Neurology Mongi-Ben Hamida (TN)
- Research Center of Neurology (RU)
- Xiangya Hospital Central South University (CN)
- Manipal Hospital (IN)
- Parkinson's Foundation (US)
- Queen Elizabeth Hospital (CN)
- Aligning Science Across Parkinson's (US)
- Institut de Recerca Sant Joan de Déu
- Indiana University School of Medicine
- University College London (GB)
- Addis Ababa University (ET)
- Shahid Beheshti University (IR)
- Rush University (US)
- McGill University (CA)
- Indiana University – Purdue University Indianapolis (US)
- University of Cincinnati (US)
- All India Institute of Medical Sciences (IN)
- University of Chile (CL)
- National Institute of Mental Health and Neurosciences (IN)
- Zhejiang University (CN)
- Medical University of Vienna (AT)
- Columbia University (US)
- University of Glasgow (GB)
- Cardiff University (GB)
- University of Otago (NZ)
- American University in Cairo (EG)
- University of Tübingen (DE)
- Ludwig-Maximilians-Universität München (DE)
- Neuroscience Research Australia (AU)
- Michigan State University (US)
- National University of Malaysia (MY)
- Centro de Estudios Científicos (CL)
- Universidad Nacional Autónoma de México (MX)
- University of Plymouth (GB)
- University of Lübeck (DE)
- University of KwaZulu-Natal (ZA)
- Tecnológico de Monterrey (MX)
- National Taipei University (TW)
Publication Details
- Journal
- npj Parkinson s Disease
- Published
- 2025-03-25
- DOI
- https://doi.org/10.1038/s41531-025-00896-2
- Citations
- 3
- Primary Topic
- Parkinson's Disease Mechanisms and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 4.17
Funders
- U.S. Department of Health and Human Services
- Michael J. Fox Foundation for Parkinson's Research
- Bristol-Myers Squibb
- Pfizer
- GlaxoSmithKline
- Sanofi
- Biogen
- CHDI Foundation
- Celgene
- Boston Scientific Corporation
- Parkinson's Foundation
- Acorda Therapeutics
- Verily Life Sciences
- Parkinson's UK
- University of Cambridge
- H. Lundbeck A/S
- National Institutes of Health
- Parkinsonfonden
- Medical Research Council
- National Institute of Neurological Disorders and Stroke