Anti-HIV Activity of Tigliane Derivatives from Euphorbia nicaeensis Roots
Five previously undescribed tigliane diterpenes (<b>1</b>-<b>4</b> and <b>7</b>), along with three known tiglianes (<b>5</b>, <b>6,</b> and <b>8</b>) were isolated from the root extract of <i>Euphorbia nicaeensis</i> using chromatographic techniques. The structures of the isolated compounds were determined using spectroscopic techniques. The isolated compounds were tested for anti-HIV activity against HIV-1 NL4.3 and HIV-2 ROD strains. Two derivatives (<b>2</b> and <b>8</b>) exhibited significant anti-HIV activity, with IC<sub>50</sub> values ranging from 1.10 to 7.47 µM. This study highlights the potential of <i>E. nicaeensis</i> root as a source of novel bioactive tigliane derivatives, warranting further investigation for possible use in HIV treatment.
Authors
- Vele Tešević (ORCID: https://orcid.org/0000-0001-7060-9055)
- Milka Jadranin (ORCID: https://orcid.org/0000-0002-4235-3504)
- Dominique Schols (ORCID: https://orcid.org/0000-0003-3256-5850)
- Karlo Wittine (ORCID: https://orcid.org/0000-0002-0936-6709)
- Slobodan Milosavljević (ORCID: https://orcid.org/0000-0002-0925-327X)
- Gordana Krstić (ORCID: https://orcid.org/0000-0001-6945-6178)
- Boris Mandić (ORCID: https://orcid.org/0000-0001-6103-7657)
- Sandra Claes (ORCID: https://orcid.org/0000-0002-9255-9199)
Institutions
- Serbian Academy of Sciences and Arts (RS)
- University of Rijeka (HR)
- Rega Institute for Medical Research (BE)
- Pliva (Croatia) (HR)
- University of Belgrade (RS)
- Institute of Chemistry, Technology and Metallurgy
Publication Details
- Journal
- Molecules
- Published
- 2025-03-25
- DOI
- https://doi.org/10.3390/molecules30071452
- Citations
- 2
- Primary Topic
- Bioactive Natural Diterpenoids Research
- Type
- article
- Field-Weighted Citation Impact
- 1.61
Funders
- Serbian Academy of Sciences and Arts