LnDOTA Releasing Probes for Luminescence and Magnetic Resonance Imaging
Lanthanide complexes of DOTA monoesters bearing nitrobenzyl and nitroimidazole groups are shown to be converted to the corresponding DOTA complexes under chemical and enzymatic conditions, giving rise to favorable changes in the luminescence properties of the europium and terbium complexes and relaxometric properties of the gadolinium complexes. The nitroimidazole complexes are converted more rapidly than their nitrobenzyl and benzyl analogues. We propose that activation of these complexes may occur by ester cleavage rather than nitro reduction and fragmentation since complexes bearing a simple benzyl group may also be cleaved under the same conditions, albeit more slowly.
Authors
- Kylie A. Vincent (ORCID: https://orcid.org/0000-0001-6444-9382)
- Stuart J. Conway (ORCID: https://orcid.org/0000-0002-5148-117X)
- Matthew F. Allen (ORCID: https://orcid.org/0000-0003-2041-246X)
- Ester M. Hammond (ORCID: https://orcid.org/0000-0002-2335-3146)
- Alexandr A. Khrapichev
- Stephen Faulkner (ORCID: https://orcid.org/0000-0003-1878-5857)
- Max Robertson
- Deborah Sneddon (ORCID: https://orcid.org/0000-0002-1229-4419)
- Lina Hacker (ORCID: https://orcid.org/0000-0001-5160-0952)
- Daria Sokolova (ORCID: https://orcid.org/0000-0003-0357-6171)
- Louise A. W. Martin
- C Foster (ORCID: https://orcid.org/0000-0002-3812-0919)
- Euan T. Sarson (ORCID: https://orcid.org/0009-0008-5023-3570)
Institutions
- University of California, Los Angeles (US)
- University of Sussex (GB)
- University of Oxford (GB)
- Université Bourgogne Franche-Comté (FR)
Publication Details
- Journal
- Inorganic Chemistry
- Published
- 2025-03-24
- DOI
- https://doi.org/10.1021/acs.inorgchem.5c00199
- Citations
- 3
- Primary Topic
- Lanthanide and Transition Metal Complexes
- Type
- article
- Field-Weighted Citation Impact
- 1.55
Funders
- Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung
- Engineering and Physical Sciences Research Council