EFFECTIVENESS OF SAFFRON IN THE TREATMENT OF MILD TO MODERATE ALZHEIMERS DISEASE WITH CDR-SB SCORE

Introduction: large levels of glucocorticoids and stress results structural and functional changes in brain and hippocampus, limbic system has akey rolein cognitive functions including learningand memory. Alzheimers disease (AD) is a chronic neurodegenerative disease. Objective: the AIM of this study was to assess the efficacy ofsaffron in the treatment of mild to moderate Alzheimers disease (AD). Methods: fifty-six patients of 55years old were eligible to participate in this study. The study is a double-blind study of parallel groups of patients with AD. Results: saffron is effective similar to donepezil in the treatment of mild to moderate AD after 22 weeks. The safety of saffron is comparatively similar like donepezil. The side effects presented with saffron and done pezil groups likely same. The major parameter taken was Alzheimers disease assessment Scale-cognitive subscale score evaluated with baseline. The safety of saffron was also recorded systemically. Participators were given a capsule saffron 30mg/day(15mg twice daily)or donepezil10mg/day(5mg twice per day). Conclusion: this studyprovides mainly suggests that possible therapeutic effect of saffron extract at least in short-term treatment of patients with mild-to0moderate Alzheimers disease.