Vitexin’s Role in Colon Cancer Apoptosis: AMPK/mTOR Pathway Modulation Explored Through Experimental and Computational Approaches
This study demonstrates that vitexin induces apoptosis in Caco-2 colon cancer cells through multiple mechanisms, including modulation of antioxidant enzymes, upregulation of pro-apoptotic factors, and regulation of key signaling pathways involved in cell survival and proliferation. These findings suggest that vitexin's mechanisms of action involve complex interactions with various cellular pathways, making it a promising candidate for further research and potential therapeutic applications in colorectal cancer.
Authors
- Yasser O. Mosaad (ORCID: https://orcid.org/0000-0003-2566-5183)
- Mohammad Shahidul Islam (ORCID: https://orcid.org/0000-0002-4612-5875)
- Mohammed A. Hussein (ORCID: https://orcid.org/0000-0002-1811-2794)
- Gaber E. Eldesoky
- Seikh Mafiz Alam (ORCID: https://orcid.org/0000-0003-1436-7316)
- Matthieu Daniel (ORCID: https://orcid.org/0000-0002-5605-3131)
- Gamila A. Farouk
- Mohamed Youssef
- Haneen Kh. Abdelkader
Institutions
- Aliah University (IN)
- Future University in Egypt (EG)
- King Saud University (SA)
- October 6 University (EG)
Publication Details
- Journal
- Recent Patents on Anti-Cancer Drug Discovery
- Published
- 2025-03-25
- DOI
- https://doi.org/10.2174/0115748928361989250226083146
- Citations
- 1
- Primary Topic
- Nutrition, Genetics, and Disease
- Type
- article
- Field-Weighted Citation Impact
- 1.82