Performance of pro brain naturetic peptide in diagnosis reduced and preserved ejection fraction heart failure

Objectives To investigate the level of pro brain naturetic peptide (BNP) in diagnosis of heart failure (HF) patients. Background HF is a complex clinical syndrome that results from either functional or structural weakening of ventricles resulting in symptomatic left ventricle (LV) dysfunction. Methods A case-control study was done on 60 subjects, divided into three groups: Group I: HF patients with preserved ejection fraction (HFpEF), Group II: HF patients with reduced ejection fraction (HFrEF) and Group III: apparently healthy controls. For all patients history was taken, general examination and echocardiography for ejection fraction (EF) were done. Lab investigations included liver functions, renal functions, hemoglobin A1C (HbA1c %) and pro BNP. The pro BNP level was assayed by enzyme linked immunosorbent assay (ELISA). Results There was statistically significant difference between the studied groups regarding pro BNP level (P