Metabolic predictors of organism dysadaptation in Yakutia

Objective: to determine the metabolic predictors of maladaptation of the body of water transport workers in Yakutia. Material and methods. A survey of 224 male workers of water transport in Yakutia was conducted. The adaptive potential (AP) is calculated on the basis of anthropometric and functional indicators of the body. Biochemical (lactate dehydrogenase (LDH), alkaline phosphatase, creatine phosphokinase, creatine kinase-MV, gamma-glutamyl-transferase, aspartate and alanine aminotransferases, glucose, total protein, albumin, triglycerides, urea, creatinine, uric acid, total cholesterol, high-density lipoprotein cholesterol) and hormonal (free fractions of triiodothyronine, thy-roxine, thyroid stimulating hormone, cortisol, testosterone) serum parameters. Low and very low density lipoproteins were calculated using the formula. Results. By the method of multiple linear regression analysis indicators as significant predictors of maladaptive processes: 4 biochemical — cholesterol ((3=0.234; p=0.001), glucose ((3=0.192; p=0.003), LDH ((3=0.170; p=0.009), triglycerides ((3=0.150; p=0.023), and 1 hormonal —testosterone ((3—0.308; p=0.002). Conclusion. Elevated cholesterol, glucose, LDH and triglyceride levels, and decreased testosterone levels have been identified as significant predictors of maladjustment in water transport workers.