XBP1s-EDEM2 Prevents the Onset and Development of HFpEF by Ameliorating Cardiac Lipotoxicity

We demonstrate a cardioprotective mechanism regulating myocardial lipid homeostasis. The findings provide a promising therapeutic target to prevent and treat HFpEF, a condition with limited treatment options.

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Publication Details

Journal
Circulation
Published
2025-03-25
DOI
https://doi.org/10.1161/circulationaha.124.072194
Citations
14
Primary Topic
Endoplasmic Reticulum Stress and Disease
Type
article
Field-Weighted Citation Impact
16.12
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article

XBP1s-EDEM2 Prevents the Onset and Development of HFpEF by Ameliorating Cardiac Lipotoxicity

Sara Missaglia, Derk Frank, Cristian Sotomayor-Flores, Katharine King et al.
14 citations
Circulation
Endoplasmic Reticulum Stress and Disease
16.12
article

XBP1s-EDEM2 Prevents the Onset and Development of HFpEF by Ameliorating Cardiac Lipotoxicity

Sara Missaglia, Derk Frank, Cristian Sotomayor-Flores, Katharine King, Martin Pool, Susanne S. Hille, Elizabeth J. Cartwright, Andrea Ruiz‐Velasco, Jessica M. Miller, Bernard D. Keavney, Rida Raja, Zhiyong Zou, Christian Pinali, Sanskruti Ravindra Gare, Martin K. Rutter, Gabriele G. Schiattarella, Luigi A. Venetucci, Namrita Kaur, Oveena Fonseka, Oliver Josef Müller, Daniela Tavian, Qinghui Ou, C. A. Ross, Eileithyia Swanton, Jiayan Zhang, Xiangjun Zhao, Riham R. E. Abouleisa, Wei Liu, Tao Wang, Xinyi Chen, Tamer Mohamed
article en
14 citations

Abstract

We demonstrate a cardioprotective mechanism regulating myocardial lipid homeostasis. The findings provide a promising therapeutic target to prevent and treat HFpEF, a condition with limited treatment options.

CirculationVol. 151(22)
Università Cattolica del Sacro Cuore (IT), University of Louisville (US), Baylor College of Medicine (US), Max Delbrück Center (DE), Manchester Academic Health Science Centre (GB), RCA (United States) (US), Hochschule für Angewandte Wissenschaften Kiel (DE), Christian-Albrechts-Universität zu Kiel (DE), Deutsches Herzzentrum der Charité (DE), German Centre for Cardiovascular Research (DE), NIHR Manchester Biomedical Research Centre (GB), Charité - Universitätsmedizin Berlin (DE)
Good health and well-being
Openalex Percentile: Top 1%
Endoplasmic Reticulum Stress and Disease
16.12
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