XBP1s-EDEM2 Prevents the Onset and Development of HFpEF by Ameliorating Cardiac Lipotoxicity
We demonstrate a cardioprotective mechanism regulating myocardial lipid homeostasis. The findings provide a promising therapeutic target to prevent and treat HFpEF, a condition with limited treatment options.
Authors
- Sara Missaglia (ORCID: https://orcid.org/0000-0001-6551-6698)
- Derk Frank (ORCID: https://orcid.org/0000-0001-7561-075X)
- Cristian Sotomayor-Flores (ORCID: https://orcid.org/0000-0001-8988-6167)
- Katharine King (ORCID: https://orcid.org/0009-0009-8075-9466)
- Martin Pool (ORCID: https://orcid.org/0000-0003-3071-1535)
- Susanne S. Hille (ORCID: https://orcid.org/0000-0002-9809-4636)
- Elizabeth J. Cartwright (ORCID: https://orcid.org/0000-0002-6836-7795)
- Andrea Ruiz‐Velasco (ORCID: https://orcid.org/0000-0003-0660-5855)
- Jessica M. Miller (ORCID: https://orcid.org/0000-0001-9154-4975)
- Bernard D. Keavney (ORCID: https://orcid.org/0000-0001-9573-0812)
- Rida Raja (ORCID: https://orcid.org/0000-0003-2965-1846)
- Zhiyong Zou (ORCID: https://orcid.org/0000-0001-5049-5425)
- Christian Pinali (ORCID: https://orcid.org/0000-0001-9815-6940)
- Sanskruti Ravindra Gare (ORCID: https://orcid.org/0009-0001-0586-7522)
- Martin K. Rutter (ORCID: https://orcid.org/0000-0001-6380-539X)
- Gabriele G. Schiattarella (ORCID: https://orcid.org/0000-0002-7582-7171)
- Luigi A. Venetucci (ORCID: https://orcid.org/0000-0002-8236-3993)
- Namrita Kaur (ORCID: https://orcid.org/0000-0001-6628-0592)
- Oveena Fonseka (ORCID: https://orcid.org/0009-0009-9949-7689)
- Oliver Josef Müller (ORCID: https://orcid.org/0000-0001-8223-2638)
- Daniela Tavian (ORCID: https://orcid.org/0000-0003-3333-0068)
- Qinghui Ou
- C. A. Ross (ORCID: https://orcid.org/0000-0001-5263-5487)
- Eileithyia Swanton (ORCID: https://orcid.org/0000-0002-3299-4228)
- Jiayan Zhang (ORCID: https://orcid.org/0000-0001-6504-8257)
- Xiangjun Zhao
- Riham R. E. Abouleisa (ORCID: https://orcid.org/0000-0001-8883-068X)
- Wei Liu (ORCID: https://orcid.org/0000-0003-1592-6693)
- Tao Wang (ORCID: https://orcid.org/0000-0003-4535-3830)
- Xinyi Chen (ORCID: https://orcid.org/0009-0005-4978-6029)
- Tamer Mohamed
Institutions
- Università Cattolica del Sacro Cuore (IT)
- University of Louisville (US)
- Baylor College of Medicine (US)
- Max Delbrück Center (DE)
- Manchester Academic Health Science Centre (GB)
- RCA (United States) (US)
- Hochschule für Angewandte Wissenschaften Kiel (DE)
- Christian-Albrechts-Universität zu Kiel (DE)
- Deutsches Herzzentrum der Charité (DE)
- German Centre for Cardiovascular Research (DE)
- NIHR Manchester Biomedical Research Centre (GB)
- Charité - Universitätsmedizin Berlin (DE)
Publication Details
- Journal
- Circulation
- Published
- 2025-03-25
- DOI
- https://doi.org/10.1161/circulationaha.124.072194
- Citations
- 14
- Primary Topic
- Endoplasmic Reticulum Stress and Disease
- Type
- article
- Field-Weighted Citation Impact
- 16.12