Global dissemination of conjugative virulence plasmids co-harboring hypervirulence and multidrug resistance genes in <i>Klebsiella pneumoniae</i>
In this study, we found that the conjugative virulence plasmids containing carbapenem resistance genes could be conjugated to <i>Klebsiella</i> strains, enabling them to express antibiotic resistance and hypervirulence-associated phenotypes simultaneously. More importantly, we observed that the global dissemination of this type of multidrug resistance and hypervirulence conjugative plasmid is lineage specific. The UMAP projection revealed that the regional variations were correlated with ST types and serotypes, which poses a global threat of the CR-hv<i>Kp</i> infection worldwide.
Authors
- Edward Wai‐Chi Chan (ORCID: https://orcid.org/0000-0002-7570-5289)
- Qi Xu (ORCID: https://orcid.org/0000-0001-8716-3096)
- Miaomiao Xie (ORCID: https://orcid.org/0000-0002-6408-2995)
- Ruan-Yang Sun (ORCID: https://orcid.org/0009-0009-5548-7147)
- Heng Heng (ORCID: https://orcid.org/0000-0003-4722-5816)
- Xiaoxuan Liu (ORCID: https://orcid.org/0000-0003-4546-4573)
- Xuemei Yang (ORCID: https://orcid.org/0000-0003-4005-978X)
- Lianwei Ye (ORCID: https://orcid.org/0000-0002-2301-9930)
- Chen Yang (ORCID: https://orcid.org/0000-0001-9876-724X)
- Rong Zhang (ORCID: https://orcid.org/0000-0002-2174-7985)
- Sheng Chen (ORCID: https://orcid.org/0000-0003-3526-7808)
Institutions
- Hong Kong Polytechnic University (HK)
- City University of Hong Kong (HK)
- Second Affiliated Hospital of Zhejiang University (CN)
Publication Details
- Journal
- mSystems
- Published
- 2025-03-25
- DOI
- https://doi.org/10.1128/msystems.01675-24
- Citations
- 9
- Primary Topic
- Antibiotic Resistance in Bacteria
- Type
- article
- Field-Weighted Citation Impact
- 5.32
Funders
- Impact Fund
- Research Grants Council, University Grants Committee
- Hong Kong Government